The impact of smoking on bronchiectasis and its comorbidities.

Autor:	de la Rosa-Carrillo D; Respiratory Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., de Granda-Orive JI; Respiratory Department, Hospital Universitario 12 de Octubre, Madrid, Spain.; School of Medicine, Complutense University, Madrid, Spain., Diab Cáceres L; Respiratory Department, Hospital Universitario 12 de Octubre, Madrid, Spain., Gutiérrez Pereyra F; Respiratory Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Raboso Moreno B; Respiratory Department, Hospital Universitario de Getafe, Getafe, Madrid, Spain., Martínez-García MÁ; Respiratory Department, La Fe University and Polytechnic Hospital, Valencia, Spain., Suárez-Cuartin G; Respiratory Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	Expert review of respiratory medicine [Expert Rev Respir Med] 2024 May; Vol. 18 (5), pp. 255-268. Date of Electronic Publication: 2024 Jun 24.
DOI:	10.1080/17476348.2024.2369716
Abstrakt:	Introduction: Bronchiectasis, characterized by irreversible bronchial dilatation, is a growing global health concern with significant morbidity. This review delves into the intricate relationship between smoking and bronchiectasis, examining its epidemiology, pathophysiology, clinical manifestations, and therapeutic approaches. Our comprehensive literature search on PubMed utilized MESH terms including 'smoking,' 'smoking cessation,' 'bronchiectasis,' and 'comorbidities' to gather relevant studies. Areas Covered: This review emphasizes the role of smoking in bronchiectasis development and exacerbation by compromising airways and immune function. Interconnected comorbidities, including chronic obstructive pulmonary disease, asthma, and gastroesophageal reflux disease, create a detrimental cycle affecting patient outcomes. Despite limited studies on smoking cessation in bronchiectasis, the review stresses its importance. Advocating for tailored cessation programs, interventions like drainage, bronchodilators, and targeted antibiotics are crucial to disrupting the inflammatory-infection-widening cycle. Expert Opinion: The importance of smoking cessation in bronchiectasis management is paramount due to its extensive negative impact on related conditions. Proactive cessation programs utilizing technology and targeted education for high-risk groups aim to reduce smoking's impact on disease progression and related comorbidities. In conclusion, a personalized approach centered on smoking cessation is deemed vital for bronchiectasis, aiming to improve outcomes and enhance patients' quality of life in the face of this complex respiratory condition.
Databáze:	MEDLINE
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