| Autor: |
Abed MN; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq., Alassaf FA; Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul, Iraq., Qazzaz ME; Department of Pharmacognosy and Medicinal Plants, College of Pharmacy, University of Mosul, Mosul, Iraq. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of bone metabolism [J Bone Metab] 2024 May; Vol. 31 (2), pp. 75-89. Date of Electronic Publication: 2024 May 31. |
| DOI: |
10.11005/jbm.2024.31.2.75 |
| Abstrakt: |
Vitamin D (ViD), plays an important role in calcium absorption and bone mineralization, is associated with bone mineral density. Severe deficiency in ViD has long been linked to conditions such as rickets in children and osteomalacia in adults, revealing its substantial role in skeletal health. Additionally, investigations show an existing interconnection between ViD and insulin resistance (Ins-R), especially in patients with type 2 diabetes mellitus (T2DM). Obesity, in conjunction with Ins-R, may augment the risk of osteoporosis and deterioration of skeletal health. This review aims to examine recent studies on the interplay between ViD, Ins-R, obesity, and their impact on skeletal health, to offer insights into potential therapeutic strategies. Cochrane Library, Google Scholar, and Pubmed were searched to investigate relevant studies until December 2023. Current research demonstrates ViD's impact on pancreatic β-cell function, systemic inflammation, and insulin action regulation. Our findings highlight an intricate association between ViD, Ins-R, obesity, and skeletal health, providing a perspective for the prevention and/or treatment of skeletal disorders in patients with obesity, Ins-R, and T2DM. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
