Retrospective Analysis of Glioblastoma Outcomes.

Autor:	Onciul R; Department of Neurosurgery, University Emergency Hospital of Bucharest, Bucharest, ROU.; Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU., Toader C; Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.; Department of Vascular Neurosurgery, National Institute of Neurology and Neurovascular Diseases, Bucharest, ROU., Glavan LA; Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU., Covache-Busuioc RA; Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU., Bratu BG; Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU., Costin HP; Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU., Corlatescu AD; Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU., Ciurea AV; Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.; Department of Neurosurgery, Sanador Clinical Hospital, Bucharest, ROU., Grama M; Department of Software, Syndical.io, Bucharest, ROU., Idu AA; Department of Neurosurgery, Carol Davila University of Medicine and Pharmacy, Bucharest, ROU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jun 16; Vol. 16 (6), pp. e62462. Date of Electronic Publication: 2024 Jun 16 (Print Publication: 2024).
DOI:	10.7759/cureus.62462
Abstrakt:	This retrospective mono-center study focuses on 144 cases of glioblastoma treated over a time span of 12 years in our clinic in Romania. We offer critical insight into the dreadful aspect of this tumor by highlighting the principal characteristics such as localization, the genetic information of each case, progression-free survival (PFS), and overall survival (OS). A tenth of our patients underwent a second surgical procedure, providing a comparable OS to the other part of our study group, proving that surgical treatment as salvage therapy is a viable option. Also, our research reinforces the fact that utilizing the Karnofsky Performance Scale is a great predictor of patient outcomes in glioblastoma patients. Even though radiotherapy and chemotherapy have mild effects in the context of this oncological disease, our research shows that O 6 -methylguanine-DNA methyltransferase (MGMT) methylation status and epidermal growth factor receptor (EGFR) amplification have an important effect on OS. Moreover, the particularity of our study, that our patients did not start adjuvant therapy right after surgery, highlighted by a low OS compared to the international literature, sheds light on the fact that chemotherapy and radiotherapy must be started right after the surgical procedure, according to the Stupp protocol. To sum up, our research takes into consideration the factors that influence patient survival and outcome in the battle against glioblastoma. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Onciul et al.)
Databáze:	MEDLINE
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