Assessment of PD-L1 Expression in Non-Small Cell Lung Cancers Using [ 68 Ga]Ga-DOTA-WL12 PET/CT.

Autor: Wu Y; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China., Xu D; Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China., Gu Y; Central Research Institute, United Imaging Healthcare Group Co., Ltd, Shanghai, 201807, China., Li G; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China., Wang H; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.; Hepatobiliary Surgery, Department of General Surgery, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, 200040, China., Cao M; Department of Thoracic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Wei W; Department of Nuclear Medicine, Institute of Clinical Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China., Wan P; Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China., Guan Y; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China., Chen X; Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China., Xie F; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jazyk: angličtina
Zdroj: Small methods [Small Methods] 2024 Jun 16, pp. e2400358. Date of Electronic Publication: 2024 Jun 16.
DOI: 10.1002/smtd.202400358
Abstrakt: Assessing programmed death ligand-1 (PD-L1) expression in non-small cell lung cancer (NSCLC), particularly in metastatic cases, remains challenging. In this study, surface plasmon resonance (SPR) analysis and [ 68 Ga]Ga-DOTA-WL12 micro-PET/CT imaging are performed. [ 68 Ga]Ga-DOTA-WL12 PET/CT and [ 18 F]FDG PET/CT are performed on a cohort of 20 patients with NSCLC. Semi-quantitative assessments include SUVmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG), and target-to-background ratio (TBR). DOTA-WL12 exhibits robust PD-L1 binding with a KD value of 0.2 nM. Subsequent human studies reveal significant correlations between PD-L1 expression and the [ 68 Ga]Ga-DOTA-WL12 SUVmax in primary and metastatic lesions, surpassing the [ 18 F]FDG results (r = 0.8889, p <0.0001 vs r = 0.0469, p = 0.8127). Notably, [ 68 Ga]Ga-DOTA-WL12 imaging discerned SUVmax and TBR differences between PD-L1 TPS ≤1% and PD-L1 TPS > 1% groups (p all <0.001). In an NSCLC patient with brain metastases, [ 68 Ga]Ga-DOTA-WL12 shows a SUVmean of 0.04 in the brain background, with TBR values of 17 and 23, underscoring its potential for detecting brain metastases. The study provides initial evidence for the clinical utility of [ 68 Ga]Ga-DOTA-WL12 PET/CT for lesion detection, immunotherapy selection, and therapeutic efficacy evaluation in PD-L1-expressing NSCLC, demonstrating its potential as a valuable tool in NSCLC research and management.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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