Effects of bisphenol A on reproduction, oxidative stress, and lipid regulation in the marine rotifer Brachionus plicatilis.

Autor: Yoon DS; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea., Kim JS; Department of Food and Nutrition, College of Bio-Nano Technology, Gachon University, Seongnam 13120, South Korea., Hong MS; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea; Department of Food and Nutrition, College of Bio-Nano Technology, Gachon University, Seongnam 13120, South Korea., Byeon E; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea., Sayed AEH; Department of Zoology, Assiut University, Assiut 71516, Egypt., Park HG; Department of Marine Ecology and Environment, College of Life Sciences, Gangneung-Wonju National University, Gangneung 25457, South Korea., Lee JS; Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, South Korea. Electronic address: jslee2@skku.edu., Lee MC; Department of Food and Nutrition, College of Bio-Nano Technology, Gachon University, Seongnam 13120, South Korea. Electronic address: mclee314@gachon.ac.kr.
Jazyk: angličtina
Zdroj: Marine pollution bulletin [Mar Pollut Bull] 2024 Aug; Vol. 205, pp. 116553. Date of Electronic Publication: 2024 Jun 15.
DOI: 10.1016/j.marpolbul.2024.116553
Abstrakt: This study reports the effects of bisphenol A (BPA) on the rotifer Brachionus plicatilis, focusing on growth performance, reproductive output, oxidative stress responses, and lipid metabolism genes. High BPA levels disrupted peak daily offspring production and led to oxidative stress and increased superoxide dismutase and catalase activity. The research identified distinctive monoacylglycerol O-acyltransferase (MGAT) and diacylglycerol O-acyltransferase (DGAT) genes in B. plicatilis, B. rotundiformis, and B. koreanus, enhancing understanding of lipid metabolism in these species. BPA exposure significantly altered MGAT and DGAT expression, and feeding status affected these regulatory patterns. When food was unavailable, BPA reduced DGAT2 and MGAT2a expression. However, under feeding conditions, DGAT2 and MGAT1 levels increased, indicating that nutritional status and BPA exposure interact to affect gene expression.
Competing Interests: Declaration of competing interest The authors declare no competing financial interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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