Salivary exosomal microRNA profile as biomonitoring tool for diagnosis and prognosis of patients with head and neck squamous cell carcinoma: a systematic review.

Autor: Sanesi L; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy. Electronic address: lorenzo.sanesi@unifg.it., Mori G; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy., Troiano G; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy., Ballini A; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy., Valzano F; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy., Dioguardi M; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy., Muzio LL; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy., Magalhaes M; Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, ON M5G 1×3, Canada., Caponio VCA; Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Jazyk: angličtina
Zdroj: Archives of oral biology [Arch Oral Biol] 2024 Sep; Vol. 165, pp. 106012. Date of Electronic Publication: 2024 May 27.
DOI: 10.1016/j.archoralbio.2024.106012
Abstrakt: Objective: Exosomes are extracellular vesicles found in saliva and other body fluids. These vesicles range in size from 30 to 150 nm and play a crucial role in intercellular communication, transporting different biomolecules, actively targeting cells. These vesicles regulate both physiological and pathological processes within recipient cells. MicroRNAs (miRs) are transported within exosomes and are delivered to target cells where they influence signaling pathways, taking on a crucial regulatory role in oncogenesis; for example, they are implicated in progression and infiltration of various cancers, such as head and neck squamous cell carcinoma (HNSCC).
Material and Methods: A systematic literature search based on specific keywords, according to the PRISMA guidelines, was carried out on PubMed, Web of Science, Scopus, and Google Scholar. Only original articles were selected during this review. The risk of bias was assessed by QUADAS-2.
Results: At the end of the selection process 9 articles were included. In these studies, 41 miRs showed differential expression between healthy subjects and patient with HNSCC. The techniques varied among studies for the extraction and analysis of exosomal miRs. We presented also salivary exosomal miRs pathways, to give insights about pathogenetic mechanisms.
Conclusions: Exosomal microRNA are promising biomarkers for HNSCC detection. MiR-10b-5p, miR-486-5p, miR-24-3p, miR-412-3p, and miR-512-3p are the most promising markers applicable to diagnostics, while miR-1307-5p and miR-519c-3p resulted overexpressed and correlated to worse survival outcomes.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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