Physical comorbidities of older age bipolar disorder (OABD) patients: A global replication analysis of prevalence and sex differences.

Autor: Teixeira AL; Biggs Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; Faculdade Santa Casa BH, Belo Horizonte, Brazil. Electronic address: teixeiraa@uthscsa.edu., Almeida OP; Medical School, University of Western Australia, Perth, Australia., Lavin P; Jewish General Hospital/Lady Davis Institute, McGill University, Montreal, Canada., Barbosa IG; Department of Psychiatry, Medical School, Minas Gerais University, Belo Horizonte, Brazil., Alda M; Department of Psychiatry, Dalhousie University, Hallifax, Nova Scotia, Canada., Altinbas K; Selçuk University Medical Faculty, Department of Psychiatry, Mazhar Osman Mood Clinic, Konya, Turkey., Balanzá-Martínez V; Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, CIBERSAM, Valencia, Spain., Briggs FBS; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA., Calkin C; Departments of Psychiatry and Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada., Chen P; Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Dols A; Amsterdam UMC, VU University, Amsterdam Neuroscience, Amsterdam, the Netherlands; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands., Eyler LT; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA., Forester BP; Department of Psychiatry, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA., Forlenza OV; Laboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Gildengers AG; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hajek T; Department of Psychiatry, Dalhousie University, Hallifax, Nova Scotia, Canada., Haarman B; University of Groningen, Groningen, the Netherlands., Korten N; Amsterdam UMC, VU University, Amsterdam Neuroscience, Amsterdam, the Netherlands; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands., Jimenez E; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, Barcelona, Catalonia, Spain; Department of Psychiatry, Hospital Universitario de Alava, BIOARABA, UPV/EHU, Vitoria, Spain; CIBERSAM, ISCIII, Spain., Lafer B; Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil., Levin JB; Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA., Montejo L; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain., Nunes PV; Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil., Olagunju AT; Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada., Oluwaniyi S; Federal Neuropsychiatric Hospital, Lagos, Nigeria., Oudega ML; GGZ in Geest Mental Health Care, Amsterdam, The Netherlands; Amsterdam UMC, VU University, Department of Psychiatry, Boelelaan 1117, Amsterdam, The Netherlands; Amsterdam Public Health, Mental Health program, Amsterdam, The Netherlands; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, The Netherlands., Patrick RE; Division of Geriatric Psychiatry, McLean Hospital, Belmont, MA, USA; Harvard Medical School, Boston, MA, USA., Radua J; IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Catalonia, Spain., Rej S; Jewish General Hospital/Lady Davis Institute, McGill University, Montreal, Canada., Schouws S; GGZ inGeest, Amsterdam UMC, VU Medical Center, Amsterdam, The Netherlands., Soares JC; Department of Psychiatry and Behavioral Sciences, University of Texas/McGovern Medical School, Houston, TX, USA., Sutherland AN; Department of Psychiatry, University of California San Diego, San Diego, CA, USA; Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, San Diego, CA, USA., Vieta E; Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Neuroscience, University of Barcelona, IDIBAPS, CIBERSAM, ISCIII, Barcelona, Catalonia, Spain., Yala J; Case Western Reserve University School of Medicine, Cleveland, OH, USA., Sajatovic M; Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Jazyk: angličtina
Zdroj: General hospital psychiatry [Gen Hosp Psychiatry] 2024 Sep-Oct; Vol. 90, pp. 6-11. Date of Electronic Publication: 2024 Jun 12.
DOI: 10.1016/j.genhosppsych.2024.06.004
Abstrakt: Objectives: To compare the prevalence of physical morbidities between older aged patients with bipolar disorder (OABD) and non-psychiatric comparisons (NC), and to analyze sex differences in prevalence.
Methods: OABD was defined as bipolar disorder among adults aged ≥50 years. Outcomes analyzed were the prevalence of diseases affecting the cardiovascular, respiratory, gastrointestinal, genitourinary, renal, musculoskeletal, and endocrine systems. The analysis used cross-sectional data of OABD participants (n = 878; mean age 60.9 ± 8.0 years, n = 496 (56%) women) from the collaborative Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) dataset and NC participants recruited at the same sites (n = 355; mean age 64.4 ± 9.7 years, n = 215 (61%) women).
Results: After controlling for sex, age, education, and smoking history, the OABD group had more cardiovascular (odds ratio [95% confidence interval]: 2.12 [1.38-3.30]), renal (5.97 [1.31-43.16]), musculoskeletal (2.09 [1.30-3.43]) and endocrine (1.90 [1.20-3.05]) diseases than NC. Women with OABD had more gastrointestinal (1.56 [0.99-2.49]), genitourinary (1.72 [1.02-2.92]), musculoskeletal (2.64 [1.66-4.37]) and endocrine (1.71 [1.08-2.73]) comorbidities than men with OABD, when age, education, smoking history, and study site were controlled.
Conclusions: This replication GAGE-BD study confirms previous findings indicating that OABD present more physical morbidities than matched comparison participants, and that this health burden is significantly greater among women.
Competing Interests: Declaration of competing interest VB-M has received honoraria from Angelini, unrelated to the present work. JBL has received grant funding from NIH, AHA, and Merck. EV has received grants and served as consultant, advisor or CME speaker for the following entities: AB-Biotics, AbbVie, Adamed, Angelini, Biogen, Biohaven, Boehringer-Ingelheim, Celon Pharma, Compass, Dainippon Sumitomo Pharma, Ethypharm, Ferrer, Gedeon Richter, GH Research, Glaxo-Smith Kline, HMNC, Idorsia, Johnson & Johnson, Lundbeck, Medincell, Merck, Novartis, Orion Corporation, Organon, Otsuka, Roche, Rovi, Sage, Sanofi-Aventis, Sunovion, Takeda, and Viatris, outside the submitted work.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: