Recent development in dual function fluorescence probes for HOCl and interaction with different bioactive molecules.

Autor: Zareen W; Institute of Chemical Sciences, Bahauddin Zakariya University, 60800, Multan, Pakistan., Ahmed N; Institute of Chemical Sciences, Bahauddin Zakariya University, 60800, Multan, Pakistan., Raza S; Institute of Chemical Sciences, Bahauddin Zakariya University, 60800, Multan, Pakistan., Ali Khan M; Institute of Chemical Sciences, Bahauddin Zakariya University, 60800, Multan, Pakistan. Electronic address: malikhan@bzu.edu.pk., Shafiq Z; Institute of Chemical Sciences, Bahauddin Zakariya University, 60800, Multan, Pakistan. Electronic address: zahidshafiq@bzu.edu.pk.
Jazyk: angličtina
Zdroj: Talanta [Talanta] 2024 Sep 01; Vol. 277, pp. 126374. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1016/j.talanta.2024.126374
Abstrakt: Reactive oxygen species (ROS), reactive sulfur species (RSS), metal ions, and nitrogen species (RNS) play important roles in a variety of biological processes, such as a signal transduction, inflammation, and neurodegenerative damage. These species, while essential for certain functions, can also induce stress-related diseases. The interrelation between ROS, RSS, Metal ions and RNS underscores the importance of quantifying their concentrations in live cells, tissues, and organisms. The review emphasizes the use of small-molecule-based fluorescent/chemodosimeter probes to effectively measure and map the species' distribution with high temporal and spatial precision, paying particular attention to in vitro and in vivo environments. These probes are recognized as valuable tools contributing to breakthroughs in modern redox biology. The review specifically addresses the relationship of HOCl/ClO ‾ (hypochlorous acid/Hypochlorite) with other reactive species. (Dual sensing probes).
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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