Genetic and environmental interactions contribute to immune variation in rewilded mice.

Autor: Oyesola O; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. oyebola.oyesola@nih.gov., Downie AE; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.; Department of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany., Howard N; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Barre RS; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.; Department of Microbiology, Immunology, and Molecular Genetics, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA., Kiwanuka K; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Zaldana K; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Department of Pathology, New York University, Grossman School of Medicine, New York, NY, USA., Chen YH; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University, Grossman School of Medicine, New York, NY, USA.; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Menezes A; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA., Lee SC; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Devlin J; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University, Grossman School of Medicine, New York, NY, USA., Mondragón-Palomino O; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Souza COS; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Herrmann C; Kimmel Center for Biology and Medicine at the Skirball Institute, New York University, Grossman School of Medicine, New York, NY, USA.; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Koralov SB; Department of Pathology, New York University, Grossman School of Medicine, New York, NY, USA., Cadwell K; Division of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA., Graham AL; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA. algraham@princeton.edu.; Santa Fe Institute, Santa Fe, NM, USA. algraham@princeton.edu., Loke P; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. png.loke@nih.gov.; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA. png.loke@nih.gov.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2024 Jul; Vol. 25 (7), pp. 1270-1282. Date of Electronic Publication: 2024 Jun 14.
DOI: 10.1038/s41590-024-01862-5
Abstrakt: The relative and synergistic contributions of genetics and environment to interindividual immune response variation remain unclear, despite implications in evolutionary biology and medicine. Here we quantify interactive effects of genotype and environment on immune traits by investigating C57BL/6, 129S1 and PWK/PhJ inbred mice, rewilded in an outdoor enclosure and infected with the parasite Trichuris muris. Whereas cellular composition was shaped by interactions between genotype and environment, cytokine response heterogeneity including IFNγ concentrations was primarily driven by genotype with consequence on worm burden. In addition, we show that other traits, such as expression of CD44, were explained mostly by genetics on T cells, whereas expression of CD44 on B cells was explained more by environment across all strains. Notably, genetic differences under laboratory conditions were decreased following rewilding. These results indicate that nonheritable influences interact with genetic factors to shape immune variation and parasite burden.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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