The Potential of Radiolabeled Bisphosphonates in SPECT and PET for Bone Imaging.
| Autor: | Ashhar Z; Department of Nuclear Medicine, Sabah Women and Children Hospital, Karung Berkunci No. 187, 88996 Kota Kinabalu, Sabah, Malaysia., Ahmad Fadzil MF; Department of Nuclear Medicine, National Cancer Institute, Putrajaya 62250, Malaysia., Hassan H; Centre for Diagnostic Nuclear Imaging (CDNI), Universiti Putra Malaysia, UPM 43400, Serdang, Selangor, Malaysia., Othman MF; Department of Pharmacy Practice, Faculty of Pharmacy, Universiti Teknologi Mara, Puncak Alam 42300, Selangor, Malaysia., Md Hassan MB; Department of Pharmacy, Hospital Kuala Lumpur, Jalan Pahang 50586, Wilayah Persekutuan Kuala Lumpur, Malaysia., Chun Vui VY; Department of Nuclear Medicine, Sabah Women and Children Hospital, Karung Berkunci No. 187, 88996 Kota Kinabalu, Sabah, Malaysia., Guat Choo C; Department of Nuclear Medicine, Sabah Women and Children Hospital, Karung Berkunci No. 187, 88996 Kota Kinabalu, Sabah, Malaysia., Yusof NA; Department of Pharmacy Chemistry, Faculty of Science, Universiti Putra Malaysia, UPM Serdang, Selangor 43400, Malaysia. |
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| Jazyk: | angličtina |
| Zdroj: | Current medical imaging [Curr Med Imaging] 2024; Vol. 20 (1), pp. e15734056270935. |
| DOI: | 10.2174/0115734056270935231113035620 |
| Abstrakt: | Skeletal-related events due to bone metastases can be prevented by early diagnosis using radiological or nuclear imaging techniques. Nuclear medicine techniques such as Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) have been used for diagnostic imaging of bone for decades. Although it is widely recognized that conventional diagnostic imaging techniques such as Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) have high sensitivity, low cost and wide availability, the specificity of both techniques is rather low compared to nuclear medicine techniques. Nuclear medicine techniques, on the other hand, have improved specificity when introduced as a hybrid imaging modality, as they can combine physiological and anatomical information. Two main radiopharmaceuticals are used in nuclear medicine: [ 99m Tc]-methyl diphosphonate ([ 99m Tc]Tc-MDP) from the generator and [ 18 F]sodium fluoride ([ 18 F]NaF) from the cyclotron. The former is used in SPECT imaging, while the latter is used in PET imaging. However, recent studies show that the role of radiolabeled bisphosphonates with gallium-68 ( 68 Ga) and fluorine-18 ( 18 F) may have a potential role in the future. This review, therefore, presents and discusses the brief method for producing current and future potential radiopharmaceuticals for bone metastases. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| Databáze: | MEDLINE |
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