Exploring the ecotoxicological impact of meropenem on Lemna minor: Growth, photosynthetic activity, and oxidative stress.

Autor: Guzman-Tordecilla M; Instituto de Estudios Hidráulicos y Ambientales (IDEHA), Departamento de Ingeniería Civil y Ambiental, Universidad del Norte, km 5 antigua vía a Puerto Colombia, Barranquilla, C.P. 081007, Colombia. Electronic address: mtordecilla@uninorte.edu.co., Pacheco-Bustos C; Instituto de Estudios Hidráulicos y Ambientales (IDEHA), Departamento de Ingeniería Civil y Ambiental, Universidad del Norte, km 5 antigua vía a Puerto Colombia, Barranquilla, C.P. 081007, Colombia., Coronado-Posada N; Environmental and Computational Chemistry Group, School of Pharmaceutical Sciences, Zaragocilla Campus, University of Cartagena, C.P. 130014, Cartagena, Colombia., Pedrosa-Gomes M; Laboratório de Fisiologia de Plantas sob Estresse, Departamento de Botânica, Setor de Ciências Biológicas, Universidade Federal do Paraná, Avenida Coronel Francisco H. dos Santos, 100, Centro Politécnico Jardim das Américas, C.P. 19031, 81531-980, Curitiba, Paraná, Brazil., Martinez-Burgos WJ; Department of Bioprocess Engineering and Biotechnology, Federal University of Paraná Centro Politécnico, Curitiba, Paraná, C.P. 81531-990, Brazil., Mejía-Marchena R; Instituto de Estudios Hidráulicos y Ambientales (IDEHA), Departamento de Ingeniería Civil y Ambiental, Universidad del Norte, km 5 antigua vía a Puerto Colombia, Barranquilla, C.P. 081007, Colombia., Zorman-Marques R; Laboratório de Fisiologia de Plantas sob Estresse, Departamento de Botânica, Setor de Ciências Biológicas, Universidade Federal do Paraná, Avenida Coronel Francisco H. dos Santos, 100, Centro Politécnico Jardim das Américas, C.P. 19031, 81531-980, Curitiba, Paraná, Brazil.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Oct 01; Vol. 258, pp. 119409. Date of Electronic Publication: 2024 Jun 11.
DOI: 10.1016/j.envres.2024.119409
Abstrakt: Meropenem is a potent carbapenem antibiotic frequently used in medical settings. Several studies have confirmed the pervasive presence of these antibiotics in wastewater treatment plants and aquatic environments. However, the effects of these substances on non-target organisms, such as plants, have not been adequately monitored. Thus, this study aimed to assess the short-term impact of meropenem on the growth, photosynthesis, chlorophyll content, and enzyme activity of the macrophyte plant Lemna minor. The methods involved exposing the plant to meropenem under controlled conditions and assessing physiological and biochemical parameters to determine the impact on photosynthetic activity and oxidative stress. These analyses included growth rate, antioxidant enzyme activity, and photosynthetic capacity. The findings suggest that the growth rate of Lemna minor remained unaffected by meropenem at concentrations <200000 μgL -1 . However, plants exposed to concentrations >20 μgL -1 showed physiological alterations, such as decreased net photosynthesis rate (17%) and chlorophyll concentration (57%), compared to the control group. For acute toxicity assays, the calculated EC 50 7-day and EC 20 7-day were 1135 μgL -1 and 33 μgL -1 , respectively. In addition, in most treatments tested, meropenem caused an increase in the superoxide dismutase (SOD), catalase (CAT) and ascorbate peroxidase (APX) activity as a defense mechanism against oxidative stress. Our results suggest that meropenem affects photosynthetic processes and induces oxidative stress in the macrophyte plant Lemna minor. Further studies are needed to assess the physiological and metabolic interactions between antibiotics and primary producers at different long-term trophic levels.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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