Personalized autologous stem cell harvesting improves patient collection outcomes.

Autor: Duarte GC; New Zealand Blood Service, 15 Lester Lane, Christchurch, New Zealand., Wei W; New Zealand Blood Service, 15 Lester Lane, Christchurch, New Zealand; Centre for Biostatistics, Division of Population Health, Health Services Research and Primary Care, The University of Manchester, Manchester M13 9PL, UK. Electronic address: Wenhua.wei@nzblood.co.nz.
Jazyk: angličtina
Zdroj: Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine [Transfus Clin Biol] 2024 Aug; Vol. 31 (3), pp. 157-161. Date of Electronic Publication: 2024 Jun 12.
DOI: 10.1016/j.tracli.2024.06.004
Abstrakt: Objectives: This study aims to demonstrate that utilizing a personalized approach to apheresis stem cell collection, can safely optimize the collection outcomes, especially in the context of poor mobilizers and high cell targets.
Background: The optimal mobilization and harvesting of peripheral blood stem cells is critical to the success of the stem cell transplant. The ideal strategy that promotes better cell yields, with sustainable use of resources and assuring patient safety, should be pursued.
Methods: PBSC collections for autologous stem cell transplant data according to a fixed-processed volume strategy (One Size Fits All) or individualized to patients CD34+ peripheral blood content and target approach (Custom-Tailored or CT) were retrospectively compared.
Results: A total of 263 collections from 142 patients were assessed. The majority of patients were male, had multiple myeloma and were mobilized with isolated G-CSF. The CT strategy promoted a significantly higher CD34+ cell yield when the pre-collection CD34 was lower than 20/µl (1.02 ± 0.16 versus 1.36 ± 0.23, p < 0.001) and also a decrease in the proportion of mobilization cycles that needed 3 apheresis (31% versus 14%, p = 0.02). There was no difference in apheresis-related adverse events between the groups.
Conclusion: Tailoring the apheresis procedures to the patient-specific characteristics and objectives, can effectively promote better patient outcome.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Société française de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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