| Autor: |
Jaisankar E; Department of Chemical Engineering, Coimbatore Institute of Technology, Coimbatore 641 014, India., Azarudeen RS; Department of Chemical Engineering, Coimbatore Institute of Technology, Coimbatore 641 014, India.; Department of Chemistry, Coimbatore Institute of Technology, Coimbatore 641 014, India., Thirumarimurugan M; Department of Chemical Engineering, Coimbatore Institute of Technology, Coimbatore 641 014, India. |
| Jazyk: |
angličtina |
| Zdroj: |
ACS applied bio materials [ACS Appl Bio Mater] 2024 Jul 15; Vol. 7 (7), pp. 4323-4338. Date of Electronic Publication: 2024 Jun 12. |
| DOI: |
10.1021/acsabm.4c00183 |
| Abstrakt: |
The polymeric nanofiber mats were produced from polylactic acid, methylcellulose, and polyethylene glycol with 5-fluorouracil (5Fu) drug and iron oxide (Fe 3 O 4 ) nanoparticles. Spectral and crystallographic studies clearly elucidated the ionic interactions, structure and nature of the mats. Fe 3 O 4 nanoparticles <10 nm in size, along with methyl cellulose and polyethylene glycol, have significantly reduced the size of nanofiber mats. The mechanical properties for the mats was found to be challenging; however, surface wettability, swelling capacity, and drug encapsulation efficiency results were promising. A controlled drug release pattern was observed from in vitro drug release study, zero-order kinetics, and a Higuchi model. Nanofiber mats showed higher anticancer activity (78%) against MDA-MB 231 cancer cells, which reveals that a small amount of 5Fu drug (15.86%) with high levels of O 2 •• , H 2 O 2 , and OH • radicals generated from Fe 3 O 4 have catalyzed the Fenton's reaction to eradicate the cancer cells, in a shorter span of 24 h, itself. In addition, the apoptosis assay by dual AO/PI staining method clearly exhibited the apoptotic cancer cells by fluorescence microscopy. Incorporation of Fe 3 O 4 nanoparticles enhanced the anticancer activity of the mats, compared to the commercially available standard 5Fu drug. Nanofiber mats significantly controlled the growth of selected pathogenic microbial strains by the action of the 5Fu drug and Fe 3+ ions. The degradation of mats was investigated by an in vitro mass loss study for a period of 360 days. In a nutshell, promising nanofiber mats were produced as targeted drug delivery devices for chemotherapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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