Neurodevelopmental outcome and quality of life in children admitted to the paediatric intensive care unit: A single-centre Australian cohort study.

Autor: Long D; School of Nursing, Faculty of Health, Queensland University of Technology, Brisbane, Australia; Child Health Research Centre, The University of Queensland, Brisbane, Australia; Paediatric Intensive Care, Queensland Children's Hospital, Brisbane, Australia. Electronic address: da.long@qut.edu.au., Minogue J; School of Nursing, Faculty of Health, Queensland University of Technology, Brisbane, Australia; Neonatal Intensive Care Unit, Mater Mother's Hospital, Brisbane, Australia., Charles K; School of Nursing, Faculty of Health, Queensland University of Technology, Brisbane, Australia; Child Health Research Centre, The University of Queensland, Brisbane, Australia; Paediatric Intensive Care, Queensland Children's Hospital, Brisbane, Australia; Herston Infectious Diseases Institute, Metro North Hospital and Health Service, Brisbane, Australia., Morgan S; Child Health Research Centre, The University of Queensland, Brisbane, Australia; Paediatric Intensive Care, Queensland Children's Hospital, Brisbane, Australia., Schults J; Child Health Research Centre, The University of Queensland, Brisbane, Australia; Paediatric Intensive Care, Queensland Children's Hospital, Brisbane, Australia; School of Nursing, Midwifery and Social Work, The University of Queensland, Brisbane, Australia; Herston Infectious Diseases Institute, Metro North Hospital and Health Service, Brisbane, Australia., Le Marsney R; Child Health Research Centre, The University of Queensland, Brisbane, Australia., Stocker C; Paediatric Intensive Care, Queensland Children's Hospital, Brisbane, Australia., Gibbons KS; Child Health Research Centre, The University of Queensland, Brisbane, Australia., Dow B; School of Nursing, Faculty of Health, Queensland University of Technology, Brisbane, Australia; Child Health Research Centre, The University of Queensland, Brisbane, Australia.
Jazyk: angličtina
Zdroj: Australian critical care : official journal of the Confederation of Australian Critical Care Nurses [Aust Crit Care] 2024 Nov; Vol. 37 (6), pp. 903-911. Date of Electronic Publication: 2024 Jun 11.
DOI: 10.1016/j.aucc.2024.05.001
Abstrakt: Background: The development of new morbidities has become increasingly identified in paediatric critical care medicine. To date, there has been limited research of long-term outcomes following paediatric critical illness in Australia.
Objectives: The objective of this study was to quantify neurodevelopmental impairments in children following paediatric intensive care unit (PICU) discharge and their association with health-related quality of life (HRQoL).
Methods: A single-centre ambidirectional cohort study at an Australian hospital. Parents of children admitted to the PICU between 2015 and 2017 were invited to participate. Neurodevelopmental outcome and HRQoL was prospectively evaluated, using the Ages and Stages Questionnaire (<5 years), Strengths and Difficulties Questionnaire (≥5 years), and Pediatric Quality of Life Inventory™, respectively.
Results: A total of 230 parents of critically ill children participated. Children were 1.9 years old (median, interquartile range [IQR]: 0.2, 7.5), male (59.6%), and ventilated (49.1%) at PICU admission. The median time to follow-up was 24.4 months (IQR: 16.3, 36.7). Parent respondents were more likely to be female (85.5%), White (88.3%), and partnered (81.1%). The incidence of overall neurodevelopmental impairment was 30% (33% in children aged <5 years; 24% in children aged ≥5 years). The incidence of poor HRQoL was 37.9%. History of developmental delay was independently associated with overall neurodevelopmental impairment (adjusted odds ratio [aOR]: 4.21, 95% confidence interval: 2.05, 8.63) and poor HRQoL (aOR: 7.29, 95% confidence interval: 3.26, 16.27). Two or more PICU admissions (aOR: 4.10, IQR: 1.82, 9.26) was also associated with poor HRQoL.
Conclusions: This is the first contemporary view of PICU long-term outcomes conducted in Australia and significantly informs ongoing research in this area. Approximately one-third of PICU survivors demonstrate neurodevelopmental impairment and reduced quality of life. Multiple domains of post-intensive care syndrome-paediatrics must be considered to have a comprehensive understanding of child outcomes. Assessment of baseline/premorbid functioning is also essential in order to understand the true impact of illness and PICU admission.
(Copyright © 2024 Australian College of Critical Care Nurses Ltd. All rights reserved.)
Databáze: MEDLINE
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