Central obesity and fat-free mass are associated with a larger spleen volume in the general population.

Autor:	Mousa MFM; Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Naeem M; Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Department of Zoology, University of Malakand, Chakdara Dir (L), Pakistan., Bibi S; Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Bülow R; Department for Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany., Bahls M; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany., Siewert-Markus U; Clinic and Polyclinic for Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Töpfer P; Department of Medical Psychology, University Medicine Greifswald, Germany., Aghdassi A; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany., Khattak MNK; Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Völzke H; Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Markus MR; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany., Ittermann T; Department of Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Jazyk:	angličtina
Zdroj:	Upsala journal of medical sciences [Ups J Med Sci] 2024 May 29; Vol. 129. Date of Electronic Publication: 2024 May 29 (Print Publication: 2024).
DOI:	10.48101/ujms.v129.10465
Abstrakt:	Background and Aim: As the spleen plays a significant role in immunity, the aim was to investigate the associations of different body composition markers derived from various sources with spleen volume in a general population sample. Materials and Methods: Cross-sectional data of 1095 individuals (570 women; 52%) aged between 30 and 90 years were collected in the Study of Health in Pomerania (SHIP-START-2). We measured spleen volume by magnetic resonance imaging (MRI).Body composition markers were derived from classic anthropometry, bioelectrical impedance analysis, including absolute fat mass (FM) and fat-free mass (FFM), as well as from MRI, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver fat content. Sex-stratified-adjusted linear regression models were used to analyze the associations of body composition markers with spleen volumes. Results: We observed positive associations of body mass index, body weight, waist circumference, hip circumference, waist-to-height ratio, absolute FM, absolute FFM, and VAT and SAT with spleen volume in men and women. An 8.12 kg higher absolute FFM was associated with a 38.4 mL (95% confidence interval [CI]: 26.7-50.1) higher spleen volume in men and a 5.21 kg higher absolute FFM with a 42.6 mL (95% CI: 26.2-59.0) higher spleen volume in women. Conclusion: Our findings indicate that obesity-related body composition markers and FFM are associated with a higher spleen volume. Particularly, higher absolute FFM showed a strong association with a larger spleen volume in both men and women. Further studies are warranted to understand the clinical significance of body composition markers on large spleen volume. Competing Interests: The authors report no conflicts of interest. (© 2024 The Author(s). Published by Upsala Medical Society.)
Databáze:	MEDLINE
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