Utility of the Milan System for Reporting Salivary Gland Cytopathology in fine needle aspiration cytology of minor salivary gland lesions.

Autor: Velez Torres JM; Department of Pathology and Laboratory Medicine, University of Miami, Miller School of Medicine, Miami, Florida. Electronic address: jveleztorres@med.miami.edu., Tjendra Y; Department of Pathology and Laboratory Medicine, University of Miami, Miller School of Medicine, Miami, Florida., Curnow P; Department of Pathology and Laboratory Medicine, University of Miami, Miller School of Medicine, Miami, Florida., Sanchez-Avila M; Department of Pathology and Laboratory Medicine, Jackson Memorial Hospital, Miami, Florida., Gomez-Fernandez C; Department of Pathology and Laboratory Medicine, University of Miami, Miller School of Medicine, Miami, Florida., Zuo Y; Department of Pathology and Laboratory Medicine, University of Miami, Miller School of Medicine, Miami, Florida., Kerr DA; Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire; Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Jazyk: angličtina
Zdroj: Journal of the American Society of Cytopathology [J Am Soc Cytopathol] 2024 Sep-Oct; Vol. 13 (5), pp. 350-358. Date of Electronic Publication: 2024 May 16.
DOI: 10.1016/j.jasc.2024.05.001
Abstrakt: Introduction: Salivary gland lesions are routinely evaluated by fine-needle aspiration cytology (FNAC) preoperatively. The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) has standardized salivary gland FNAC reporting. Its application in major salivary glands (MSGs) has been well-established; however, its utility in minor salivary glands (MiSGs) is not well-known. We studied the utility of MSRSGC in MiSG FNAC.
Materials and Methods: A retrospective search of MiSG FNACs from 2 academic institutions (2006-2023) was performed. FNACs were classified using the MSRSGC. Histologic data were reviewed and recorded. The risk of malignancy (ROM), risk of neoplasia (RON), diagnostic accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated.
Results: The series included 43 MiSG FNAC (24 males and 18 females), with a mean age of 55 years (range 10-92). Aspirated sites included the following: palate, buccal space, floor of mouth, lip, tongue, and maxillary sinus. FNACs were classified as nondiagnostic (1), nonneoplastic (3), atypia of undetermined significance (6), benign neoplasm (9), salivary gland neoplasm of uncertain malignant potential (15), suspicious for malignancy, (2) and malignant (7). The risk of neoplasia and risk of malignancy were 87% and 39%. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 100%, respectively.
Conclusions: Milan System for Reporting Salivary Gland Cytopathology offers valuable information for stratifying MiSG lesions. However, the distribution and the range of diagnostic entities encountered differ somewhat from those in MSGs. For instance, mucinous cyst contents may warrant unique consideration in MiSG; while an atypical classification is recommended in MSGs, the high prevalence of mucoceles in MiSG may tilt this group toward benignity.
(Copyright © 2024 American Society of Cytopathology. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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