From network pharmacology to molecular docking analysis of sterubin targets for Alzheimer.
| Autor: | Viswanathan S; Department of Pharmacology, Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution), Puducherry - 605006, India., Arumugam T; Department of Pharmacology, Central Animal House, JIPMER, Puducherry - 605006., Sivaraj R; Department of Pharmacology, Aarupadai Veedu Medical College & Hospital, Puducherry 607402., Subhashri Rajendran S; Department of Pharmacology, Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution), Puducherry - 605006, India., Ramesh V; Department of Pharmacology, Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution), Puducherry - 605006, India., Subramanian K; Department of Pharmacology, Mother Theresa Post Graduate & Research Institute of Health Sciences (Government of Puducherry Institution), Puducherry - 605006, India., Vasanthi AHR; Department of Biotechnology, Pondicherry University - 605014. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Bioinformation [Bioinformation] 2024 Apr 30; Vol. 20 (4), pp. 327-336. Date of Electronic Publication: 2024 Apr 30 (Print Publication: 2024). |
| DOI: | 10.6026/973206300200327 |
| Abstrakt: | Sterubin (7-O-Methyleriodicytol), a flavanone compound isolated from the leaves of Eriodicyton californicum and Eriodicyton angustifolium, has neuroprotective, anti-inflammatory, and antioxidant properties. Therefore, it is of interest to identify the potential targets for Alzheimer disease using network pharmacology. We report 25 overlapping targets among 100 potential targets of sterubin and 673 known targets of Alzheimer. APP, BACE-1, and AChE were among the ten hub targets enriched in biological processes and pathways relevant to Alzheimer's disease. Subsequent, molecular docking analysis shows that sterubin have optimal binding features with these hub gene targets for further consideration. (© 2024 Biomedical Informatics.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|