Patterns of use of primary and first-line chemotherapy for recurrence among patients with cervical cancer.

Autor:	Diggs A; Columbia University College of Physicians and Surgeons, New York, New York, USA.; New York Presbyterian Hospital, New York, New York, USA., Huang Y; Columbia University College of Physicians and Surgeons, New York, New York, USA., Melamed A; Department of Obstetrics & Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA., Szamreta E; Merck & Co Inc, Rahway, New Jersey, USA., Monberg MJ; Merck & Co Inc, Rahway, New Jersey, USA., Hershman D; Columbia University College of Physicians and Surgeons, New York, New York, USA.; New York Presbyterian Hospital, New York, New York, USA.; Merck & Co Inc, Rahway, New Jersey, USA., Wright JD; Columbia University College of Physicians and Surgeons, New York, New York, USA jw2459@cumc.columbia.edu.; New York Presbyterian Hospital, New York, New York, USA.; Merck & Co Inc, Rahway, New Jersey, USA.
Jazyk:	angličtina
Zdroj:	International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 2024 Jul 01; Vol. 34 (7), pp. 1001-1010. Date of Electronic Publication: 2024 Jul 01.
DOI:	10.1136/ijgc-2023-004860
Abstrakt:	Background: Little is known about real-world patterns of chemotherapy use in patients with cervical cancer. Objective: To examine the patterns of chemotherapy use in patients with cervical cancer METHODS: We identified patients with cervical cancer in the IBM MarketScan Database who underwent primary hysterectomy or radiation therapy between 2011 and 2020 and described their treatment in the primary setting and at first recurrence. Results: We identified 5390 patients: 2667 (49.5%) underwent primary hysterectomy and 2723 (50.5%) primary radiotherapy. Among patients who underwent primary hysterectomy, 979 (36.7%) received adjuvant radiation, and 617 (23.1%) received primary chemotherapy. The most common chemotherapy regimens were single-agent platinum (51.7%), platinum combination therapy (42.9%), and non-platinum (3.4%). Among patients treated with primary radiation, 73.6% received primary/concurrent chemotherapy, either platinum alone (66.4% of those who received chemotherapy), platinum combinations (32.2%), or non-platinum (1.4%). The median duration of primary chemotherapy was 1.2 months. Therapy for recurrent cervical cancer was initiated in 959 patients. The most common regimens were platinum combination (63.9%), non-platinum cytotoxic agents (16.5%), single-agent platinum (14.9%), targeted therapy with bevacizumab (6.0%), and immunotherapy with pembrolizumab (3.2%). Overall, the proportion of patients treated with single-agent platinum therapy increased from 17.4% in 2011 to 32.1% in 2019, while platinum combinations decreased from 64.1% to 41.5% over the same years. Use of non-platinum agents increased from 18.5% in 2011 to 32.9% in 2018 and 26.4% in 2019. Conclusions: Platinum-based chemotherapy is the most commonly used therapy in patients with cervical cancer in the primary setting and at the time of recurrence. The rate of use of non-platinum agents at first recurrence has increased over time. Competing Interests: Competing interests: JDW has received royalties from UpToDate. ES and MJM are employees and stockholders of Merck. (© IGCS and ESGO 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu