Screening blood donors for malaria, can we increase the number of eligible donors? An observational retrospective study.

Autor:	Corbacho-Loarte MD; Infectious Diseases Department, National Referral Unit for Tropical Disease, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain. mdcorbacho@hotmail.com.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. mdcorbacho@hotmail.com., Martín O; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.; Microbiology Department, National Referral Unit for Tropical Disease, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain., Chamorro-Tojeiro S; Infectious Diseases Department, National Referral Unit for Tropical Disease, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain., Crespillo-Andújar C; Infectious Diseases Department, National Referral Unit for Tropical Disease, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain., Norman FF; Infectious Diseases Department, National Referral Unit for Tropical Disease, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain., Pérez-Molina JA; Infectious Diseases Department, National Referral Unit for Tropical Disease, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain., Sanz MG; Infectious Diseases Department, National Referral Unit for Tropical Disease, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain., Cancio-Suárez MR; Infectious Diseases Department, National Referral Unit for Tropical Disease, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain., Ruiz-Calvo G; Biostatistics Department, Hospital Ramón y Cajal. IRYCIS, Madrid, Spain., López AR; Regional Transfusion Center, Madrid, Spain., Rubio JM; National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain., López-Vélez R; Infectious Diseases Department, National Referral Unit for Tropical Disease, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain., Monge-Maillo B; Infectious Diseases Department, National Referral Unit for Tropical Disease, Hospital Ramón y Cajal, IRYCIS, Madrid, Spain. begomongem@gmail.com.; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. begomongem@gmail.com.
Jazyk:	angličtina
Zdroj:	Malaria journal [Malar J] 2024 Jun 06; Vol. 23 (1), pp. 179. Date of Electronic Publication: 2024 Jun 06.
DOI:	10.1186/s12936-024-04966-3
Abstrakt:	Background: In non-endemic countries, malaria can be transmitted through blood donations from imported cases. To ensure standards of quality and safety of human blood, the European Union and Spanish national law, requires a deferral period, or a screening by immunological or genomic test among those donors with potential risk of malaria. Scientific societies, European Committee on Blood Transfusion, and Spanish Society of Haematology and Haemotherapy, refer only to the result of the immunological test. Methods: An observational retrospective study was performed in potential donors with a positive immunological test for malaria done in the Regional Transfusion Center in Madrid and referred to the National Reference Unit for Tropical Diseases in Madrid between 2015-2020. At consultation a Polymerase Chain Reaction (PCR) for malaria was performed. Results: During the study period, 121 possible donors attended for consultation at NRU-Trop. Median age: 38.5 (IQR:33-48); median time to consultation was 32 months (IQR:12.5-110). Eighty-two (67.8%) donors were migrants and thirty-nine were travellers (32.2%). ELISA values were available for 109 subjects (90.1%), 56 individual left malaria endemic area > 3 years before. All donors tested negative for Plasmodium spp PCR test (n = 121, 100%). Conclusions: None of the subjects with a positive immunologic test deferred as blood donors had a positive genomic test. The presence of Plasmodium spp in collected blood was not detected by molecular techniques. To avoid the loss of potential blood donors, especially those with low incidence red blood cell antigens, as more precise microbiology techniques become available, updating the existing legislation becomes necessary to increase the availability of donated blood. (© 2024. The Author(s).)
Databáze:	MEDLINE
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