Correspondence between the alcohol-P3 event-related potential and alcohol reward phenotypes among young adults.

Autor: Acuff SF; Department of Psychology, The University of Memphis, Memphis, Tennessee, USA.; Recovery Research Institute, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA., Cofresí RU; Department of Psychological Sciences, University of Missouri, Columbia, Missouri, USA., Varner A; Department of Psychology, The University of Memphis, Memphis, Tennessee, USA., Dennhardt AA; Department of Psychology, The University of Memphis, Memphis, Tennessee, USA., Sable JJ; Department of Psychology, The University of Memphis, Memphis, Tennessee, USA.; Department of Behavioral Sciences, Christian Brothers University, Memphis, Tennessee, USA., Bartholow BD; Department of Psychological Sciences, University of Missouri, Columbia, Missouri, USA., MacKillop J; Peter Boris Centre for Addiction Research, McMaster University, Hamilton, Ontario, Canada., Murphy JG; Department of Psychology, The University of Memphis, Memphis, Tennessee, USA.
Jazyk: angličtina
Zdroj: Alcohol, clinical & experimental research [Alcohol Clin Exp Res (Hoboken)] 2024 Jul; Vol. 48 (7), pp. 1302-1312. Date of Electronic Publication: 2024 Jun 03.
DOI: 10.1111/acer.15377
Abstrakt: Background: Behavioral economic theory suggests that the value of alcohol depends upon elements of the choice context, such that increasing constraints on alternatives (e.g., price) or increasing the benefits of alcohol (e.g., social context) may result in greater likelihood of heavy drinking. The P3 event-related potential elicited by alcohol-related cues, a proposed marker of incentive salience, may be an electrophysiological parallel for behavioral economic alcohol demand. However, these indices have not been connected in prior research, and studies typically do not disaggregate social influences in the context of alcohol cue reactivity.
Method: The current study recruited heavy drinking young adults (N = 81) who completed measures of alcohol use and alcohol demand, in addition to a 2 (social/nonsocial) × 2 (alcohol/nonalcohol) visual oddball task to elicit the P3.
Results: In multilevel models controlling for demographic characteristics, P3 reactivity was greater to alcohol (p < 0.001) and social (p < 0.001) cues than to nonalcohol and nonsocial cues, but without a significant interaction. Higher alcohol consumption (p = 0.02) and lower elasticity of demand (p = 0.01) were associated with greater P3 response to alcohol than nonalcohol cues.
Conclusions: The results highlight a brain-behavior connection that may be an important marker for alcohol reward across units of analysis and may be sensitive to changes in the economic choice contexts that influence the likelihood of alcohol use.
(© 2024 Research Society on Alcohol.)
Databáze: MEDLINE
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