The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E 2 , while Cftr regulates de novo mucus release in response to carbamylcholine.
Autor: | Ljungholm PL; Department of Physiology, University of Gothenburg, Medicinaregatan 11, Box 432, 405 30, Gothenburg, Sweden., Ermund A; Department of Medical Chemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden., Söderlund Garsveden MM; Department of Physiology, University of Gothenburg, Medicinaregatan 11, Box 432, 405 30, Gothenburg, Sweden., Pettersson VL; Department of Physiology, University of Gothenburg, Medicinaregatan 11, Box 432, 405 30, Gothenburg, Sweden., Gustafsson JK; Department of Physiology, University of Gothenburg, Medicinaregatan 11, Box 432, 405 30, Gothenburg, Sweden. jenny.gustafsson@gu.se.; Department of Medical Chemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden. jenny.gustafsson@gu.se. |
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Jazyk: | angličtina |
Zdroj: | Pflugers Archiv : European journal of physiology [Pflugers Arch] 2024 Aug; Vol. 476 (8), pp. 1209-1219. Date of Electronic Publication: 2024 Jun 03. |
DOI: | 10.1007/s00424-024-02975-4 |
Abstrakt: | The intestinal epithelium is covered by mucus that protects the tissue from the luminal content. Studies have shown that anion secretion via the cystic fibrosis conductance regulator (Cftr) regulates mucus formation in the small intestine. However, mechanisms regulating mucus formation in the colon are less understood. The aim of this study was to explore the role of anion transport in the regulation of mucus formation during steady state and in response to carbamylcholine (CCh) and prostaglandin E (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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