Low dose insulin infusion versus the standard dose in children with diabetic ketoacidosis: a meta-analysis.

Autor:	Belal MM; Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Medical Research Group of Egypt (MRGE), Cairo, Egypt., Khalefa BB; Medical Research Group of Egypt (MRGE), Cairo, Egypt.; Faculty of Medicine, Ain shams University, Cairo, Egypt., Rabea EM; Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Medical Research Group of Egypt (MRGE), Cairo, Egypt., Aly Yassin MN; Medical Research Group of Egypt (MRGE), Cairo, Egypt.; Faculty of Medicine, Helwan University, Cairo, Egypt., Bashir MN; Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Medical Research Group of Egypt (MRGE), Cairo, Egypt., Abd El-Hameed MM; Medical Research Group of Egypt (MRGE), Cairo, Egypt.; Faculty of Medicine, Zagazig University, Ash Sharqia, Egypt., Elkoumi O; Medical Research Group of Egypt (MRGE), Cairo, Egypt.; Faculty of Medicine, Suez University, Suez, Egypt., Saad SM; Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Medical Research Group of Egypt (MRGE), Cairo, Egypt., Saad LM; Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Medical Research Group of Egypt (MRGE), Cairo, Egypt., Elkasaby MH; Medical Research Group of Egypt (MRGE), Cairo, Egypt.; Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	Future science OA [Future Sci OA] 2024 May 14; Vol. 10 (1), pp. FSO956. Date of Electronic Publication: 2024 May 14 (Print Publication: 2024).
DOI:	10.2144/fsoa-2023-0137
Abstrakt:	Aim: This systematic review aims to consolidate findings from current clinical trials that compare the effectiveness of insulin infusion at 0.05 IU/kg/h versus 0.1 IU/kg/h in managing pediatric diabetic ketoacidosis. Methods: We searched several databases, including PubMed, Embase, Scopus, Cochrane Central and Web of Science. Our primary outcomes were time to reach blood glucose ≤250 mg/dl and time to resolution of acidosis. Secondary outcomes included rate of blood glucose decrease per hour, incidence of hypoglycemia, hypokalemia, treatment failure, and cerebral edema. Results & conclusion: The present study establishes that a low insulin dose exhibits comparable efficacy to the standard dosage for managing pediatric patients suffering from diabetic ketoacidosis, with a lower incidence of complications. Competing Interests: The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. (© 2024 The Authors.)
Databáze:	MEDLINE
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