The impact of chronic pain on brain gene expression.

Autor:	Collier L; Department of Biological Sciences, Columbia University, New York City, NY.; Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT., Seah C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY., Hicks EM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY., Holtzheimer PE; National Center for PTSD, U.S. Department of Veterans Affairs.; Department of Psychiatry, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA., Krystal JH; Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT.; Clinical Neuroscience Division, National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT., Girgenti MJ; Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT.; Clinical Neuroscience Division, National Center for PTSD, VA Connecticut Healthcare System, West Haven, CT., Huckins LM; Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT., Johnston KJA; Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2024 May 21. Date of Electronic Publication: 2024 May 21.
DOI:	10.1101/2024.05.20.24307630
Abstrakt:	Background: Chronic pain affects one fifth of American adults, contributing significant public health burden. Chronic pain mechanisms can be further understood through investigating brain gene expression. Methods: We tested differentially expressed genes (DEGs) in chronic pain, migraine, lifetime fentanyl and oxymorphone use, and with chronic pain genetic risk in four brain regions (dACC, DLPFC, MeA, BLA) and imputed cell type expression data from 304 postmortem donors. We compared findings across traits and with independent transcriptomics resources, and performed gene-set enrichment. Results: We identified two chronic pain DEGs: B4GALT and VEGFB in bulk dACC. We found over 2000 (primarily BLA microglia) chronic pain cell type DEGs. Findings were enriched for mouse microglia pain genes, and for hypoxia and immune response. Cross-trait DEG overlap was minimal. Conclusions: Chronic pain-associated gene expression is heterogeneous across cell type, largely distinct from that in pain-related traits, and shows BLA microglia are a key cell type.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu