The Effect of Omega-3 Supplementation on Heart Failure Outcome: A Meta-Analysis of Randomized Clinical Trial.

Autor:	Dwiputra B; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, DKI Jakarta, Indonesia., Ambari AM; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, DKI Jakarta, Indonesia., Desandri DR; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, DKI Jakarta, Indonesia., Purwowiyoto BS; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, DKI Jakarta, Indonesia., Radi B; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, DKI Jakarta, Indonesia., Pandhita BAW; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, DKI Jakarta, Indonesia., Fatrin S; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, DKI Jakarta, Indonesia., Santoso A; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - Harapan Kita National Cardiovascular Center, DKI Jakarta, Indonesia.
Jazyk:	angličtina
Zdroj:	Journal of lipid and atherosclerosis [J Lipid Atheroscler] 2024 May; Vol. 13 (2), pp. 89-96. Date of Electronic Publication: 2023 Dec 07.
DOI:	10.12997/jla.2024.13.2.89
Abstrakt:	The effect of omega-3 supplementation on cardiovascular (CV) disease has been widely studied in several large clinical trials. However, the evidence of the effect of omega-3 supplementation in patients with heart failure (HF) remains controversial. This meta-analysis investigated the effects of omega-3 supplementation on patients with HF. We conducted a literature search on MEDLINE, Embase, and Cochrane databases for clinical trials and preprints of relevant articles. Following a literature search and critical appraisal, 5 studies were included in the meta-analysis. The pooling of the result of the studies shows that there were no significant association between omega-3 supplementation and CV mortality (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.84-1.05, p =0.16) nor hospitalization due to HF (OR, 0.94; 95% CI, 0.88-1.02; p =0.13). Our systematic review and meta-analysis showed that omega-3 supplementation has no beneficial effect in patients with HF. Competing Interests: Conflict of Interest: The authors have no conflicts of interest to declare. (© 2024 The Korean Society of Lipid and Atherosclerosis.)
Databáze:	MEDLINE
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