Point prevalence of evidence-based antimicrobial use among hospitalized patients in sub-Saharan Africa: a systematic review and meta-analysis.

Autor: Boltena MT; Ethiopian Evidence Based Health Care Centre: A Joanna Briggs Institute's Center of Excellence, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia. minyahil.tadesse@ahri.gov.et.; Armauer Hansen Research Institute, Ministry of Health, Addis Ababa, Ethiopia. minyahil.tadesse@ahri.gov.et., Wolde M; Ethiopian Evidence Based Health Care Centre: A Joanna Briggs Institute's Center of Excellence, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia.; University of Technology Sydney, Sydney, Australia., Hailu B; Armauer Hansen Research Institute, Ministry of Health, Addis Ababa, Ethiopia., El-Khatib Z; Global Public Health Department, Karolinska Institute, Solna, Sweden., Steck V; Department of Pharmacology and Therapeutics, Faculty of Life Sciences, McGill University, Montreal, Canada., Woldegerima S; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Siraneh Y; Ethiopian Evidence Based Health Care Centre: A Joanna Briggs Institute's Center of Excellence, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia., Morankar S; Ethiopian Evidence Based Health Care Centre: A Joanna Briggs Institute's Center of Excellence, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jun 02; Vol. 14 (1), pp. 12652. Date of Electronic Publication: 2024 Jun 02.
DOI: 10.1038/s41598-024-62651-6
Abstrakt: Excessive and improper use of antibiotics causes antimicrobial resistance which is a major threat to global health security. Hospitals in sub-Saharan Africa (SSA) has the highest prevalence of antibiotic use. This systematic review and meta-analysis aimed to determine the pooled point prevalence (PPP) of evidence-based antimicrobial use among hospitalized patients in SSA. Literature was retrieved from CINAHL, EMBASE, Google Scholar, PubMed, Scopus, and Web of Science databases. Meta-analysis was conducted using STATA version 17. Forest plots using the random-effect model were used to present the findings. The heterogeneity and publication bias were assessed using the I 2  statistics and Egger's test. The protocol was registered in PROSPERO with code CRD42023404075. The review was conducted according to PRISMA guidelines. A total of 26, 272 study participants reported by twenty-eight studies published from 10 countries in SSA were included. The pooled point prevalence of antimicrobial use in SSA were 64%. The pooled estimate of hospital wards with the highest antibiotic use were intensive care unit (89%). The pooled prevalence of the most common clinical indication for antibiotic use were community acquired infection (41%). The pooled point prevalence of antimicrobial use among hospitalized patients were higher in SSA. Higher use of antibiotics was recorded in intensive care units. Community acquired infection were most common clinical case among hospitalized patients. Health systems in SSA must design innovative digital health interventions to optimize clinicians adhere to evidence-based prescribing guidelines and improve antimicrobial stewardship.
(© 2024. The Author(s).)
Databáze: MEDLINE
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