Actin depolymerizing factor destrin governs cell migration in neural development during Xenopus embryogenesis.

Autor:	Kim Y; KNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea., Lee HK; KNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea., Park KY; KNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea., Ismail T; KNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea., Lee H; KNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea., Ryu HY; KNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea., Cho DH; KNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea., Kwon TK; Department of Immunology, School of Medicine, Keimyung University, Daegu 41566, Korea., Park TJ; Department of Biological Sciences, College of Information-Bio Convergence, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea., Kwon T; Department of Biomedical Engineering, College of Information-Bio Convergence, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea., Lee HS; KNU G-LAMP Project Group, KNU Institute of Basic Sciences, BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Korea. Electronic address: leeh@knu.ac.kr.
Jazyk:	angličtina
Zdroj:	Molecules and cells [Mol Cells] 2024 Jun; Vol. 47 (6), pp. 100076. Date of Electronic Publication: 2024 May 31.
DOI:	10.1016/j.mocell.2024.100076
Abstrakt:	The actin-based cytoskeleton is considered a fundamental driving force for cell differentiation and development. Destrin (Dstn), a member of the actin-depolymerizing factor family, regulates actin dynamics by treadmilling actin filaments and increasing globular actin pools. However, the specific developmental roles of dstn have yet to be fully elucidated. Here, we investigated the physiological functions of dstn during early embryonic development using Xenopus laevis as an experimental model organism. dstn is expressed in anterior neural tissue and neural plate during Xenopus embryogenesis. Depleting dstn promoted morphants with short body axes and small heads. Moreover, dstn inhibition extended the neural plate region, impairing cell migration and distribution during neurulation. In addition to the neural plate, dstn knockdown perturbed neural crest cell migration. Our data suggest new insights for understanding the roles of actin dynamics in embryonic neural development, simultaneously presenting a new challenge for studying the complex networks governing cell migration involving actin dynamics. Competing Interests: Declaration of Competing Interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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