APOE genotype, eicosapentaenoic acid (EPA) supplementation and n-3 highly unsaturated fatty acid (HUFA) levels in patients with multiple colorectal polyps: A secondary analysis of the seAFOod polyp prevention trial.

Autor: Sun G; Leeds Institute of Medical Research, University of Leeds, UK., Davies JR; Leeds Institute of Medical Research, University of Leeds, UK., Mell T; Leeds Institute of Medical Research, University of Leeds, UK., Harland M; Leeds Institute of Medical Research, University of Leeds, UK., Saleh RMH; Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK; Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt., Race AD; Institute of Cancer Therapeutics, University of Bradford, UK., Loadman PM; Institute of Cancer Therapeutics, University of Bradford, UK., Williams EA; School of Medicine and Population Health, University of Sheffield, UK., Minihane AM; Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, UK; Norwich Institute of Health Ageing, Norwich, UK., Hull MA; Leeds Institute of Medical Research, University of Leeds, UK. Electronic address: M.A.Hull@leeds.ac.uk.
Jazyk: angličtina
Zdroj: Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2024 Feb; Vol. 201, pp. 102623. Date of Electronic Publication: 2024 May 31.
DOI: 10.1016/j.plefa.2024.102623
Abstrakt: Introduction: We examined the relationship between Apolipoprotein E (APOE) genotype and n-3 highly unsaturated fatty acid (HUFA) levels in participants of the seAFOod trial, who were undergoing colonoscopy surveillance after removal of colorectal polyps.
Methods: Baseline and on-treatment (eicosapentaenoic acid [EPA] 2 g daily or placebo for 6 months) levels of n-3 HUFAs, and plasma 18-hydroxyeicosapentaenoic acid (HEPE), were analysed according to APOE genotype (based on polymorphisms rs429358 and rs7412) in 584 participants.
Results: Before treatment, APOE2/2 individuals had lower levels, and APOE4/4 participants had higher levels, of n-3 HUFAs, including EPA, than APOE3/3 counterparts (P < 0.01 for the APOE2/2 versus APOE4/4 comparison). After EPA supplementation, n-3 HUFA levels were not significantly different when stratified by APOE genotype, although APOE4 carriers displayed lower plasma 18-HEPE levels than individuals without an APOE4 allele (P = 0.002).
Conclusions: APOE genotype is associated with differential n-3 HUFA and 18-HEPE levels in individuals with multiple colorectal polyps.
Competing Interests: Declaration of competing interest The Authors declare no potential Conflicts of Interest
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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