Seroprevalence of measles antibodies in the Italian general population in 2019-2020.

Autor: Grassi T; Dept. of Experimental Medicine, University of Salento, Lecce, Italy. Electronic address: tiziana.grassi@unisalento.it., Bagordo F; Dept. of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy., Rota MC; Dept. of Infectious Diseases, Italian Institute of Health (ISS), Roma, Italy., Dettori M; Dept. of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy., Baldovin T; Dept. of Cardiac, Thoracic, Vascular Sciences and Public Health, Hygiene and Public Health Unit, University of Padua, Padua, Italy., Napolitano F; Dept. of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Panico A; Dept. of Experimental Medicine, University of Salento, Lecce, Italy., Massaro E; Dept. of Health Sciences, University of Genova, Genova, Italy., Marchi S; Dept. of Molecular and Developmental Medicine, University of Siena, Siena, Italy., Furfaro G; S.C. Biochimica Clinica (Baldi e Riberi), A.O.U. Città della Salute e della Scienza, Turin, Italy., Immordino P; Dept. of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties 'G. D'Alessandro', University of Palermo, Palermo, Italy., Savio M; Dept. of Public Health, OU of Hygiene, LHU Ferrara, Ferrara, Italy., Gabutti G; National Coordinator of the Working Group 'Vaccines and Immunization Policies', Italian Society of Hygiene, Preventive Medicine and Public Health, Italy.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Sep 17; Vol. 42 (22), pp. 126012. Date of Electronic Publication: 2024 May 31.
DOI: 10.1016/j.vaccine.2024.05.060
Abstrakt: In Italy, the measles elimination target has not yet been reached despite a significant reduction in cases. A multicenter study was conducted to estimate the prevalence of anti-measles (MV) IgG antibodies in the Italian population by age, sex and geographical area. To determine the level of MV-specific antibodies in sera, the immunoenzymatic assay ELISA was used (Enzygnost Anti-VZV/IgG, Siemens Healthcare Diagnostic Products GmbH, Germany). Overall, 3746 serum samples collected in the years 2019-20 from healthy subjects aged 6-64 years residing in 13 Italian regions. The overall seroprevalence of anti-MV IgG was 91.2 % (90.6 % male, 91.7 % female). Significantly higher seroprevalence values (p < 0.05) were recorded for the extreme age groups of the study population (6-9 years: 94.2 %; 40-64 years: 97.6 %). Subjects 20-39 and 40-64 years old had significantly higher antibody titers suggesting a protection against measles mainly derived from natural infection. Seroprevalence was significantly higher in the South (93.2 %) than in the Northern-Central Italy (88.9 %). The results indicate an increase in the overall seroprevalence data compared to previous investigations. However, further efforts must be made to implement and maintain high measles vaccination coverage to avoid the risk of future epidemic outbreaks.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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