Synthesis and anti-tumor activities of three newly designed organotin(IV) carboxylates complexes.

Autor: He J; School of Preclinical Medicine, Wannan Medical College, Wuhu 241002, People's Republic of China., Wang Y; School of pharmacy, Wannan Medical College, Wuhu 241002, People's Republic of China., Su C; School of Clinical Medicine, Wannan Medical College, Wuhu 241002, People's Republic of China., Hu Y; School of Clinical Medicine, Wannan Medical College, Wuhu 241002, People's Republic of China., Hu W; Reproductive Medicine Center of the First Affiliated Hospital of Wannan Medical College, Wuhu 241002, People's Republic of China., Hu L; School of pharmacy, Wannan Medical College, Wuhu 241002, People's Republic of China. Electronic address: hulei@wnmc.edu.cn., Wang H; School of pharmacy, Wannan Medical College, Wuhu 241002, People's Republic of China. Electronic address: wanghias@126.com.
Jazyk: angličtina
Zdroj: Journal of inorganic biochemistry [J Inorg Biochem] 2024 Sep; Vol. 258, pp. 112609. Date of Electronic Publication: 2024 May 18.
DOI: 10.1016/j.jinorgbio.2024.112609
Abstrakt: Three distinctive end group-containing organotin (IV) carboxylates complexes (YDCOOSn, CLCOOSn and BZCOOSn) were designed and synthesized. Together with theoretical calculations, a thorough examination was carried out to investigate the photophysical properties of these compounds. The cytotoxicity of the synthesized compounds was tested using normal cell line GES-1 and was assessed against four cancer cell lines (A549, Hela, H1299 and HepG2). The outcomes of the experiments demonstrated that these complexes had superior selectivity than cisplatin towards cancerous cells, particularly in the A549 cell line. BZCOOSn was selected as a candidate compound for additional research because it exhibited the lowest IC 50 value and the most impressive inducing effect on cell death and G2/M phase arrest. Increased caspase-3 and -9 enzyme activity, a decline in mitochondrial membrane potential (MMP), characteristic nuclear apoptotic morphology, and an accumulation of intracellular reactive oxygen species (ROS) were seen in A549 exposed to BZCOOSn. These findings demonstrated that BZCOOSn exhibited strong cytotoxicity by triggering cell death in A549 via the mitochondrial route. Furthermore, using the scratch wound healing assay, it was discovered that BZCOOSn reduced the migration of A549 cancerous cells. These data all pointed to BZCOOSn as a possible candidate for more research and development as a chemotherapeutic drug.
Competing Interests: Declaration of competing interest We certify that none of the work disclosed in this publication may have been influenced by any known conflicting financial interests or personal relationships.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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