Comparative Analysis of Tenecteplase versus Alteplase in Acute Ischemic Stroke: A Multicentric Observational Study from Eastern India.

Autor: Dutta A; Department of Neurology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India., Gupta S; Department of Neurology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India., Chakraborty U; Department of Neurology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India., Mondal C; Department of Neurology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India., Banerjee S; Department of Neurology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India., Das D; Department of Neurosciences, Calcutta Medical Research Institute, Kolkata, West Bengal, India., Jatua SK; Department of General Medicine, Diamond Harbour Government Medical College and Hospital, Diamond Harbour, West Bengal, India., Chakrabarty S; Department of General Medicine, Barasat Government Medical College and Hospital, Kolkata, West Bengal, India., Misra S; Department of General Medicine, Tamralipto Government Medical College and Hospital, Tamluk, West Bengal, India., Bhattacharya J; Department of General Medicine, Suri District Hospital, Birbhum, West Bengal, India., Datta SK; Department of General Medicine, Vidyasagar State General Hospital, Kolkata, West Bengal, India., Ghosh S; Department of General Medicine, Vidyasagar State General Hospital, Kolkata, West Bengal, India., Sanyal D; Department of Psychiatry, KPC Medical College and Hospital, Kolkata, West Bengal, India., Sarkar A; Department of Health and Family Welfare, Public Health Branch, Government of West Bengal, India., Ray BK; Department of Neurology, Institute of Postgraduate Medical Education and Research, Kolkata, West Bengal, India.
Jazyk: angličtina
Zdroj: Annals of Indian Academy of Neurology [Ann Indian Acad Neurol] 2024 May 01; Vol. 27 (3), pp. 269-273. Date of Electronic Publication: 2024 May 20.
DOI: 10.4103/aian.aian_59_24
Abstrakt: Background: Tenecteplase is used as an alternative to alteplase and is considered noninferior for thrombolysis in acute ischemic stroke.
Objectives: To compare the effectiveness and adverse effects of tenecteplase and alteplase in the real-world management of acute ischemic stroke.
Materials and Methods: In this retrospective observational study, we collected data from acute ischemic stroke patients admitted in six hospitals in West Bengal, India, and were thrombolysed with tenecteplase or alteplase between July 2021 and June 2022. Demographic data, baseline parameters, hospital course, and 3-month follow-up data were collected. The percentage of patients achieving a score of 0-2 in the modified Ranking scale at 3 months, rate of symptomatic intracranial hemorrhage, and all-cause mortality within 3 months were the main parameters of comparison between the two thrombolytic agents.
Results: A total of 162 patients were initially included in this study. Eight patients were excluded due to unavailability of follow-up data. Among the remaining patients, 71 patients received tenecteplase and 83 patients received alteplase. There was no statistically significant difference between tenecteplase and alteplase with respect to the percentage of patients achieving functional independence (modified Rankin scale score 0-2) at 3 months (53.5% vs. 60.2%, P = 0.706), rate of symptomatic intracranial hemorrhage (5.6% vs. 10.8%, P = 0.246), and all-cause mortality at 3 months (11.3% vs. 15.7%, P = 0.628).
Conclusion: The effectiveness of tenecteplase is comparable to alteplase in the real-world management of acute ischemic stroke. Symptomatic intracranial hemorrhage and all-cause mortality rates are also similar in real-world practice.
(Copyright © 2024 Copyright: © 2024 Annals of Indian Academy of Neurology.)
Databáze: MEDLINE
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