White blood cell count nadir to zero following intensive chemotherapy as a predictive factor for patients with acute myeloid leukemia.

Autor:	Fang J; School of Medicine, University of Colorado, Aurora, Colorado, USA., Bosma G; Division of Medicine-Hematology, University of Colorado, Aurora, Colorado, USA., Aisner D; Division of Pathology, University of Colorado, Aurora, Colorado, USA., McMahon C; Division of Medicine-Hematology, University of Colorado, Aurora, Colorado, USA., Amaya M; Division of Medicine-Hematology, University of Colorado, Aurora, Colorado, USA., Schwartz M; Division of Medicine-Hematology, University of Colorado, Aurora, Colorado, USA., Kaiser J; Division of Medicine-Hematology, University of Colorado, Aurora, Colorado, USA., Abbott D; Division of Medicine-Hematology, University of Colorado, Aurora, Colorado, USA., Pan Z; Division of Pathology, University of Colorado, Aurora, Colorado, USA., Schowinsky J; Division of Pathology, University of Colorado, Aurora, Colorado, USA., Pang C; Division of Pathology, University of Colorado, Aurora, Colorado, USA., Gutman JA; Division of Medicine-Hematology, University of Colorado, Aurora, Colorado, USA., Pollyea DA; Division of Medicine-Hematology, University of Colorado, Aurora, Colorado, USA.
Jazyk:	angličtina
Zdroj:	Leukemia & lymphoma [Leuk Lymphoma] 2024 Jun; Vol. 65 (6), pp. 800-807. Date of Electronic Publication: 2024 Mar 03.
DOI:	10.1080/10428194.2024.2323677
Abstrakt:	Predictors for response to intensive therapy in AML have focused on baseline factors: percent leukemic blasts in marrow, cytogenetic/molecular genetic abnormalities, and presence of secondary AML. Non-baseline dynamic factors, occurring after induction but before response, may be useful for decisions related to salvage chemotherapy. We hypothesized white blood cell (WBC) count nadir after induction may be a real time indicator of treatment efficacy. We also examined whether time to stem cell transplant (SCT) or baseline molecular genetic abnormalities are associated with a low nadir. Data showed WBC nadir = 0 was a negative predictor for response to intensive induction and was correlated with reduced overall survival and progression free survival. Patients with WBC nadir = 0 did not have a significantly longer time to SCT, and none of the mutations increased the likelihood of reaching WBC nadir = 0. WBC nadir may be a useful real-time monitor in AML patients receiving intensive induction chemotherapy.
Databáze:	MEDLINE
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