Association of Periodontal Red Complex Bacteria With the Incidence of Gastrointestinal Cancers: A Systematic Review and Meta-Analysis.

Autor:	Kaliamoorthy S; Department of Dentistry, Vinayaka Missions Medical College and Hospital, Vinayaka Missions Research Foundation, Karaikal, IND., Priya Sayeeram S; Department of Prosthodontics, Government Dental College and Hospital, The Tamil Nadu Dr. MGR Medical University, Pudukkottai, IND., Gowdhaman N; Departmentof Physiology, Dhanalakshmi Srinivasan Medical College and Hospital, The Tamil Nadu Dr. MGR Medical University, Perambalur, IND., Jayaraj M; Department of Oral and Maxillofacial Pathology, Chettinad Dental College and Research Institute, The Tamil Nadu Dr. MGR Medical University, Chennai, IND., Radhika B; Department of Periodontics, Chettinad Dental College and Research Institute, The Tamil Nadu Dr. MGR Medical University, Chennai, IND., Chellapandi S; Department of Periodontics, Chettinad Dental College and Research Institute, The Tamil Nadu Dr. MGR Medical University, Chennai, IND., Elumalai A; Department of Periodontics, Chettinad Dental College and Research Institute, The Tamil Nadu Dr. MGR Medical University, Chennai, IND., Archana SP; Department of Oral Medicine and Radiology, Chettinad Dental College and Research Institute, The Tamil Nadu Dr. MGR Medical University, Chennai, IND., Raju K; Department of Oral Medicine and Radiology, Chettinad Dental College and Research Institute, The Tamil Nadu Dr. MGR Medical University, Chennai, IND., Palla S; Department of Oral Medicine and Radiology, Sun Dental Care, Chennai, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Apr 29; Vol. 16 (4), pp. e59251. Date of Electronic Publication: 2024 Apr 29 (Print Publication: 2024).
DOI:	10.7759/cureus.59251
Abstrakt:	Porphyromonas gingivalis is the primary microbe in the "periodontal red complex" bacteria (PRCB) along with Tannerella forsythia and Treponema denticola , which are linked to periodontal disease (PD). These pathogens are also implicated in various systemic disorders, but their association with the incidence of gastrointestinal (GI) cancer is less explored. A systematic review followed by a meta-analysis was conducted as per standard guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2022) to find this association between GI cancers and PRCB after a literature search for full-text papers in the English language (between 2010 and 2023) in databases (Cochrane Library, PubMed, and Web of Science) with suitable keywords using the Boolean search strategy. Data extraction involved titles, abstracts, and full texts retrieved and scored by the modified Newcastle-Ottawa Scale. The data were analyzed by the Review Manager (RevMan 5.2, Cochrane Collaboration, Denmark). Standard Cochran Q test and I 2 statistics (for heterogeneity) and a random effects model (pooled OR with 95% CI) were applied to report results. P. gingivalis among the PRCB was linked to GI cancers (OR: 2.16; 95% CI: 1.34-3.47). T. forsythia and T. denticola did not show meaningful associations as per existing evidence for GI cancers. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Kaliamoorthy et al.)
Databáze:	MEDLINE
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