A neurocomputational view of the effects of Parkinson's disease on speech production.

Autor:	Manes JL; Department of Speech, Language, and Hearing Sciences, Boston University, Boston, MA, United States.; Department of Communicative Disorders and Sciences, University at Buffalo, Buffalo, NY, United States., Bullock L; Program in Speech and Hearing Bioscience and Technology, Division of Medical Sciences, Harvard Medical School, Boston, MA, United States.; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, United States.; Harvard Medical School, Boston, MA, United States., Meier AM; Department of Speech, Language, and Hearing Sciences, Boston University, Boston, MA, United States., Turner RS; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, United States., Richardson RM; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, United States.; Harvard Medical School, Boston, MA, United States., Guenther FH; Department of Speech, Language, and Hearing Sciences, Boston University, Boston, MA, United States.; Department of Biomedical Engineering, Boston University, Boston, MA, United States.; Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in human neuroscience [Front Hum Neurosci] 2024 May 15; Vol. 18, pp. 1383714. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024).
DOI:	10.3389/fnhum.2024.1383714
Abstrakt:	The purpose of this article is to review the scientific literature concerning speech in Parkinson's disease (PD) with reference to the DIVA/GODIVA neurocomputational modeling framework. Within this theoretical view, the basal ganglia (BG) contribute to several different aspects of speech motor learning and execution. First, the BG are posited to play a role in the initiation and scaling of speech movements. Within the DIVA/GODIVA framework, initiation and scaling are carried out by initiation map nodes in the supplementary motor area acting in concert with the BG. Reduced support of the initiation map from the BG in PD would result in reduced movement intensity as well as susceptibility to early termination of movement. A second proposed role concerns the learning of common speech sequences, such as phoneme sequences comprising words; this view receives support from the animal literature as well as studies identifying speech sequence learning deficits in PD. Third, the BG may play a role in the temporary buffering and sequencing of longer speech utterances such as phrases during conversational speech. Although the literature does not support a critical role for the BG in representing sequence order (since incorrectly ordered speech is not characteristic of PD), the BG are posited to contribute to the scaling of individual movements in the sequence, including increasing movement intensity for emphatic stress on key words. Therapeutic interventions for PD have inconsistent effects on speech. In contrast to dopaminergic treatments, which typically either leave speech unchanged or lead to minor improvements, deep brain stimulation (DBS) can degrade speech in some cases and improve it in others. However, cases of degradation may be due to unintended stimulation of efferent motor projections to the speech articulators. Findings of spared speech after bilateral pallidotomy appear to indicate that any role played by the BG in adult speech must be supplementary rather than mandatory, with the sequential order of well-learned sequences apparently represented elsewhere (e.g., in cortico-cortical projections). Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Manes, Bullock, Meier, Turner, Richardson and Guenther.)
Databáze:	MEDLINE
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