Cross-ancestry genome-wide association studies of brain imaging phenotypes.

Autor: Fu J; Department of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China., Zhang Q; Department of Radiology, Characteristic Medical Center of Chinese People's Armed Police Force, Tianjin, China., Wang J; Department of Bioinformatics, the Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China., Wang M; Department of Radiology, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, China.; Biomedical Institute, Henan Academy of Sciences, Zhengzhou, China., Zhang B; Department of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China., Zhu W; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Qiu S; Department of Medical Imaging, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, China., Geng Z; Department of Medical Imaging, the Second Hospital of Hebei Medical University, Shijiazhuang, China., Cui G; Functional and Molecular Imaging Key Lab of Shaanxi Province and Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, China., Yu Y; Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei, China., Liao W; Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.; Molecular Imaging Research Center of Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China., Zhang H; Department of Radiology, the First Hospital of Shanxi Medical University, Taiyuan, China., Gao B; Department of Radiology, the Affiliated Hospital of Guizhou Medical University, Guiyang, China.; Department of Radiology, Yantai Yuhuangding Hospital, Yantai, China., Xu X; Department of Radiology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China., Han T; Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China., Yao Z; Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China., Qin W; Department of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China., Liu F; Department of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China., Liang M; School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China., Wang S; School of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University, Tianjin, China., Xu Q; Department of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China., Xu J; Department of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China., Zhang P; Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China., Li W; Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China., Shi D; Department of Radiology, Henan Provincial People's Hospital and Zhengzhou University People's Hospital, Zhengzhou, China., Wang C; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Lui S; Department of Radiology, Huaxi MR Research Center, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.; Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China., Yan Z; Department of Radiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China., Chen F; Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China., Zhang J; Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, China.; Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou, China., Li J; Department of Radiology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China., Shen W; Department of Radiology, Tianjin First Center Hospital, Tianjin, China., Miao Y; Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian, China., Wang D; Department of Radiology, Qilu Hospital of Shandong University, Jinan, China., Xian J; Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Gao JH; Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China., Zhang X; Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China., Xu K; Department of Radiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Zuo XN; Developmental Population Neuroscience Research Center at IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.; Institute of Psychology, Chinese Academy of Sciences, Beijing, China., Zhang L; Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China., Ye Z; Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China., Cheng J; Department of Magnetic Resonance Imaging, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. cjr.chjl@vip.163.com., Li MJ; Department of Bioinformatics, the Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. mulin@tmu.edu.cn., Yu C; Department of Radiology, Tianjin Key Laboratory of Functional Imaging and State Key Laboratory of Experimental Hematology, Tianjin Medical University General Hospital, Tianjin, China. chunshuiyu@tmu.edu.cn.; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. chunshuiyu@tmu.edu.cn.
Jazyk: angličtina
Zdroj: Nature genetics [Nat Genet] 2024 Jun; Vol. 56 (6), pp. 1110-1120. Date of Electronic Publication: 2024 May 29.
DOI: 10.1038/s41588-024-01766-y
Abstrakt: Genome-wide association studies of brain imaging phenotypes are mainly performed in European populations, but other populations are severely under-represented. Here, we conducted Chinese-alone and cross-ancestry genome-wide association studies of 3,414 brain imaging phenotypes in 7,058 Chinese Han and 33,224 white British participants. We identified 38 new associations in Chinese-alone analyses and 486 additional new associations in cross-ancestry meta-analyses at P < 1.46 × 10 -11 for discovery and P < 0.05 for replication. We pooled significant autosomal associations identified by single- or cross-ancestry analyses into 6,443 independent associations, which showed uneven distribution in the genome and the phenotype subgroups. We further divided them into 44 associations with different effect sizes and 3,557 associations with similar effect sizes between ancestries. Loci of these associations were shared with 15 brain-related non-imaging traits including cognition and neuropsychiatric disorders. Our results provide a valuable catalog of genetic associations for brain imaging phenotypes in more diverse populations.
(© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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