Inhibiting the Aggregation of Aβ by Natural Product Molecules.

Autor: Bai SC; School of Future Technology, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China., Wang YC; Fuzhou Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, China.; College of Chemical Engineering, Fuzhou University, Fuzhou, Fujian 350108, China., Li XZ; Fuzhou Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, China., Li G; Fuzhou Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, China.; Fujian-Taiwan-Hongkong-Macao Science and Technology Co-operation Base of Intelligent Pharmaceutics, Minjiang University, Fuzhou, Fujian 350108, China.
Jazyk: angličtina
Zdroj: ChemMedChem [ChemMedChem] 2024 Sep 02; Vol. 19 (17), pp. e202400223. Date of Electronic Publication: 2024 Jul 15.
DOI: 10.1002/cmdc.202400223
Abstrakt: The abnormal aggregation of Aβ has been considered one of the primary causative factors for Alzheimer's disease. Diverse molecular entities have been developed to mitigate the formation of toxic Aβ aggregates within the brain by inhibiting Aβ aggregation. Recognizing that many FDA-approved drugs are derived from natural products, we present a summary of recent discoveries involving natural product molecules with inhibitory effects on Aβ aggregation. By consolidating these findings, our review offers researchers a concise overview of the latest advancements in natural product-based interventions for Alzheimer's disease.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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