Color-reversible fluorescence tracking for the dynamic interaction of SO 2 with Hg 2+ in living cells.

Autor: Xin F; School of Science, Dalian Maritime University, Dalian 116026, PR China., Wang X; School of Science, Dalian Maritime University, Dalian 116026, PR China., Wang H; School of Science, Dalian Maritime University, Dalian 116026, PR China., Yang Y; School of Science, Dalian Maritime University, Dalian 116026, PR China., Xing M; School of Science, Dalian Maritime University, Dalian 116026, PR China., Wang H; School of Science, Dalian Maritime University, Dalian 116026, PR China., Fu Y; School of Science, Dalian Maritime University, Dalian 116026, PR China., Tian Y; School of Science, Dalian Maritime University, Dalian 116026, PR China. Electronic address: tianying@dlmu.edu.cn., Tian Y; College of Materials Science and Engineering, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, PR China. Electronic address: yongtian@szu.edu.cn.
Jazyk: angličtina
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 Oct 05; Vol. 318, pp. 124530. Date of Electronic Publication: 2024 May 24.
DOI: 10.1016/j.saa.2024.124530
Abstrakt: Mercury ion (Hg 2+ ) is one of the most threatening substances to human health, and the mercury poisoning can damage physiological homeostasis severely in human, even cause death. Intriguingly, Sulfur dioxide (SO 2 ), a gas signal molecule in human, can specifically interact with Hg 2+ for relieving mercury poisoning. However, the dynamic interaction of Hg 2+ with SO 2 at the tempospatial level and the correlation between Hg 2+ and SO 2 in the pathological process of mercury poisoning are still elusive. Herein, we rationally designed a reversible and dual color fluorescent probe (CCS) for dynamically visualizing Hg 2+ and SO 2 and deciphering their interrelationship in mercury poisoning. CCS held good sensitivity, selectivity and reversibility to Hg 2+ and SO 2 , that enabled CCS to specifically detect SO 2 and Hg 2+ via cyan fluorescence channel (centered around 485 nm) and red fluorescence channel (centered around 679 nm), respectively. Notably, the separate fluorescence signal changes of CCS realized the dynamic tracing of Hg 2+ and SO 2 in living cells, and presented the potential for exploring the correlation between SO 2 and Hg 2+ in mercury poisoning.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: