Carotid and Vertebral Atherosclerosis in West African Stroke Patients: Findings from the Stroke Investigative Research and Education Network.

Autor:	Omisore A; Obafemi Awolowo University (OAU) and Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile Ife, Nigeria., Ogbole G; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Agunloye A; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Akinyemi J; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Akpalu A; Department of Medicine, University of Ghana Medical School, Accra, Ghana., Sarfo F; Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Akpa O; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Gebregziabher M; Medical University of South Carolina, Charleston, South Carolina, USA., Arulogun O; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Komolafe M; Obafemi Awolowo University (OAU) and Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile Ife, Nigeria., Wahab K; University of Ilorin Teaching Hospital (UITH), Ilorin, Nigeria., Jenkins C; Medical University of South Carolina, South Carolina, USA., Osaigbovo G; Jos University Teaching Hospital (JUTH), Jos, Nigeria., Obiako R; Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria., Owolabi L; Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria., Fakunle A; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Ikubor J; Delta State University Teaching Hospital (DELSUTH), Oghara, Nigeria., Salaam A; Jos University Teaching Hospital (JUTH), Jos, Nigeria., Famurewa O; Obafemi Awolowo University (OAU) and Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile Ife, Nigeria., Adebayo O; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Asaleye C; Obafemi Awolowo University (OAU) and Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile Ife, Nigeria., Akisanya C; Federal Medical Centre, Abeokuta, Nigeria., Olabinri E; Federal Teaching Hospital, Ido, Nigeria., Egberongbe A; Federal Medical Center, Owo, Nigeria., Fawale M; Obafemi Awolowo University (OAU) and Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile Ife, Nigeria., Olowookere S; Obafemi Awolowo University (OAU) and Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile Ife, Nigeria., Imoh L; Jos University Teaching Hospital (JUTH), Jos, Nigeria., Adeleye O; Federal Medical Centre, Abeokuta, Nigeria., Efidi R; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Tiwari H; University of Alabama, Birmingham, USA., Mensah Y; Department of Medicine, University of Ghana Medical School, Accra, Ghana., Calys-Tagoe B; Department of Medicine, University of Ghana Medical School, Accra, Ghana., Akintunde A; LAUTECH Teaching Hospital (LTH), Ogbomoso, Nigeria., Ogunjimi L; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Olugbo O; Delta State University Teaching Hospital (DELSUTH), Oghara, Nigeria., Aridegbe M; Federal Medical Centre, Abeokuta, Nigeria., Abdullahi M; Federal Medical Center, Owo, Nigeria., Sumonu T; Federal Medical Center, Owo, Nigeria., Sanni T; Federal Teaching Hospital, Ido, Nigeria., Ogah O; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Adeoye A; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria., Uvere E; Blossom Specialist Medical Center, Ibadan, Nigeria., Ibinaiye P; Ahmadu Bello University Teaching Hospital (ABUTH), Zaria, Nigeria., Akinyemi R; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria.; Federal Medical Centre, Abeokuta, Nigeria.; Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan, Nigeria., Ovbiagele B; Weill Institute for Neurosciences, University of California San-Francisco, USA., Owolabi M; College of Medicine, University of Ibadan, Ibadan, Nigeria and University College Hospital Ibadan, Nigeria.; Blossom Specialist Medical Center, Ibadan, Nigeria.; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria, University College Hospital Ibadan.
Jazyk:	angličtina
Zdroj:	Nigerian medical journal : journal of the Nigeria Medical Association [Niger Med J] 2022 Sep 11; Vol. 63 (2), pp. 98-111. Date of Electronic Publication: 2022 Sep 11 (Print Publication: 2022).
Abstrakt:	Background: We evaluated the characteristics of carotid and vertebral atherosclerosis in indigenous West Africans with stroke. Methodology: Of the 3778stroke patients recruited between 01/2014 and 08/2017, 1070 (28.3%) received carotid and vertebral artery evaluation with B-mode Ultrasound. Carotid and vertebral intima-media thickness (IMT) using multiple site technique were measured bilaterally and plaque frequency was determined. Descriptive and comparative analyses between stroke types and vessels were carried out. Results: There were 809 (75.6%) patients with ischemic stroke. The prevalence of intima-media thickening in the study population was 84.0% (898/1070) [95% CI: 81.7-86.1], being higher in the ischemic stroke (688/809, 85.0%) [95% CI: 82.4-87.3] than in the hemorrhagic stroke group (211/261, 80.8%) [95% CI: 75.6-85.2]. Overall prevalence of plaques which was 26.1% [95% CI: 23.5-28.8], was found also to be higher in ischemic than hemorrhagic stroke (29.8%[95% CI: 26.7-33.0] vs. 14.6% [95% CI: 10.8-19.4], p < 0.05). The mean IMT (carotids: 2.01+1.33 mm; vertebrals: 0.96+0.54mm, p<0.001) and prevalence of plaques (carotids: 8.8%; vertebrals: 1.7%,p<0.001) were higher in carotid than vertebral arteries. Age, hypertension, level of formal education, history of smoking, average monthly income, and family histories of hypertension and stroke were associated with intima-media thickening in the carotids (all p< 0.05) in the ischemic stroke patients while family history of hypertension, diabetes mellitus, and level of formal education were independently associated with intima-media thickening in the carotids (all p< 0.05) in the hemorrhagic stroke patients. No CVRF showed an independent association with the presence of plaque in the carotid and vertebral arteries both stroke types. Conclusions: One off our stroke patients in our cohort had atherosclerotic plaques, with ischemic patients being twice as likely to have this burden compared to hemorrhagic patients, and carotid atherosclerosis being five times as frequent as vertebral atherosclerosis. (Copyright © 2022 Nigerian Medical Association.)
Databáze:	MEDLINE
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