Increased vascular stiffness in children exposed in utero but not children exposed postnatally to emissions from a coal mine fire.

Autor: Hemstock EJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Air Pollution, Energy and Health Research, NHMRC CRE, Glebe, New South Wales, Australia., Bigaran A; Department of Surgery, Faculty of Medicine, Science and Dentistry, University of Melbourne, Melbourne, Victoria, Australia.; Wellness and Supportive Care, Olivia Newton-John Cancer Research and Wellness Centre, Austin Health, Victoria, Australia., Allgood S; School of Rural Health, Monash University, Churchill, Victoria, Australia., Wheeler AJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Commonwealth Scientific and Industrial Research Organization, Environment, Aspendale, Victoria, Australia., Dalton M; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Williamson GJ; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia., Gao CX; Centre for Youth Mental Health (Orygen), University of Melbourne, Parkville, Victoria, Australia.; School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Abramson MJ; Centre for Air Pollution, Energy and Health Research, NHMRC CRE, Glebe, New South Wales, Australia.; School of Public Health & Preventive Medicine, Monash University, Melbourne, Victoria, Australia., Negishi K; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Sydney Medical School Nepean, University of Sydney, Sydney, New South Wales, Australia.; Nepean Hospital, Kingswood, New South Wales, Australia., Johnston FH; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Air Pollution, Energy and Health Research, NHMRC CRE, Glebe, New South Wales, Australia., Zosky GR; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Air Pollution, Energy and Health Research, NHMRC CRE, Glebe, New South Wales, Australia.; Tasmanian School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Jazyk: angličtina
Zdroj: Environmental epidemiology (Philadelphia, Pa.) [Environ Epidemiol] 2024 Apr 12; Vol. 8 (3), pp. e309. Date of Electronic Publication: 2024 Apr 12 (Print Publication: 2024).
DOI: 10.1097/EE9.0000000000000309
Abstrakt: Background: Chronic, low-intensity air pollution exposure has been consistently associated with increased atherosclerosis in adults. However, there was limited research regarding the implications of acute, high-intensity air pollution exposure during childhood. We aimed to determine whether there were any associations between early-life exposure to such an episode and early-life vascular function changes.
Methods: We conducted a prospective cohort study of children (<9 years old) who lived in the vicinity of the Hazelwood coal mine fire (n = 206). Vascular function was measured using noninvasive diagnostic methods including carotid intima-media thickness and pulse wave velocity (PWV). Exposure estimates were calculated from prognostic models and location diaries during the exposure period completed by each participant's parent. Linear mixed-effects models were used to determine whether there were any associations between exposure and changes in vascular outcomes at the 3- and 7-year follow-ups and over time.
Results: At the 7-year follow-up, each 10 μg/m 3 increase in daily PM 2.5 in utero was associated with increased PWV ( β = 0.13 m/s; 95% confidence interval [CI] = 0.02, 0.24; P = 0.02). The association between in utero exposure to daily PM 2.5 was not altered by adjustment for covariates, body mass index, and maternal fire stress. Each 1 µg/m 3 increase in background PM 2.5 was associated with increased PWV ( β = 0.68 m/s; 95% CI = 0.10, 1.26; P = 0.025), in children from the in utero exposure group. There was a trend toward smaller PWV ( β = -0.17 m/s; 95% CI = -0.366, 0.02) from the 3- to 7-year follow-up clinic suggesting that the deficits observed previously in children exposed postnatally did not persist.
Conclusion: There was a moderate improvement in vascular stiffness of children exposed to PM 2.5 from a local coal mine fire in infancy. There was a mild increase in vascular stiffness in children exposed to PM 2.5 from a local coal mine fire while their mothers were pregnant.
Competing Interests: E.J.H., A.B., S.A., A.J.W., M.D., G.J.W., C.X.G., K.N., F.H.J., and G.R.Z. declare that they have no conflicts of interest with regard to the content of this report. M.J.A. reports a relationship with Pfizer Global Research and Development that includes funding grants. M.J.A. reports a relationship with Boehringer Ingelheim GmbH that includes funding grants. M.J.A. reports a relationship with Sanofi Australia that includes consulting or advisory, and funding grants. M.J.A. reports a relationship with GlaxoSmithKline that includes funding grants and speaking and lecture fees.
(Copyright © 2024 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved.)
Databáze: MEDLINE
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