| Autor: |
Pérez-Santana CG; Instituto Universitario de Sanidad Animal y Seguridad Alimentaria (IUSA), Universidad de Las Palmas de Gran Canaria (ULPGC), Arucas, 35400 Las Palmas, Spain.; Unidad de Investigación Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010 Las Palmas, Spain.; Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010 Las Palmas, Spain., Jiménez-Alonso AA; Instituto Universitario de Sanidad Animal y Seguridad Alimentaria (IUSA), Universidad de Las Palmas de Gran Canaria (ULPGC), Arucas, 35400 Las Palmas, Spain.; Unidad de Investigación Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010 Las Palmas, Spain., Rodríguez-Esparragón F; Unidad de Investigación Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010 Las Palmas, Spain.; Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010 Las Palmas, Spain., Cazorla-Rivero S; Unidad de Investigación Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010 Las Palmas, Spain.; Departamento de Medicina Interna, Universidad de La Laguna, Tenerife, 38200 La Laguna, Spain., Rodríguez Grau-Bassas E; Instituto Universitario de Sanidad Animal y Seguridad Alimentaria (IUSA), Universidad de Las Palmas de Gran Canaria (ULPGC), Arucas, 35400 Las Palmas, Spain.; Unidad de Investigación Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, 35010 Las Palmas, Spain. |
| Abstrakt: |
Twelve dogs with oral malignant melanomas (MM) were evaluated in this study, with demographic details indicating a balanced distribution of gender, age, and weight among various breeds. Tumor locations varied, with diverse surgical procedures being performed, including mandibulectomies and maxillectomies. Lymphadenectomies were conducted, revealing a 16.66% metastatic rate in regional lymph nodes. At the time of surgery, clinical staging identified stages I, II, and III, with most cases having non-infiltrated margins and a high mitotic index. Follow-up revealed local recurrences and metastases, prompting additional surgeries and affecting survival rates. This study reports varying outcomes, with some dogs completing one year without recurrence, while others experienced progressive disease, leading to six oral melanoma-related deaths. The characteristics of melanotic melanoma and amelanotic melanoma are observed in order to study differences between them, the degree of aggressiveness, the mortality rate and the possibility of future therapeutic targets. Although high pigmentation has been correlated with a better outcome, we could not find any significant correlation between survival and achromia. Oral benign melanomas might exist, and this could justify variabilities between stage and survival; however, carefulness is required due to their unpredictable behavior. The findings underscore the complexity of oral melanoma cases and highlight the need for further research on effective management strategies. |
