Enhancement of Vascularization and Ovarian Follicle Survival Using Stem Cells in Cryopreserved Ovarian Tissue Transplantation-A Systematic Review.

Autor: Zaninović L; Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.; Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, Petrova ulica 13, 10 000 Zagreb, Croatia.; School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia., Bašković M; Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.; School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.; Department of Pediatric Surgery, Children's Hospital Zagreb, Ulica Vjekoslava Klaića 16, 10 000 Zagreb, Croatia.; Croatian Academy of Medical Sciences, Kaptol 15, 10 000 Zagreb, Croatia., Ježek D; Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.; School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.; Department of Histology and Embryology, School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.; Department of Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, Kišpatićeva ulica 12, 10 000 Zagreb, Croatia., Habek D; School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.; Croatian Academy of Medical Sciences, Kaptol 15, 10 000 Zagreb, Croatia.; Department of Obstetrics and Gynecology, Clinical Hospital Merkur, Zajčeva ulica 19, 10 000 Zagreb, Croatia.; School of Medicine, Catholic University of Croatia, Ilica 242, 10 000 Zagreb, Croatia., Pogorelić Z; Department of Pediatric Surgery, University Hospital of Split, Spinčićeva ulica 1, 21 000 Split, Croatia.; School of Medicine, University of Split, Šoltanska ulica 2a, 21 000 Split, Croatia., Katušić Bojanac A; Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.; School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.; Department of Medical Biology, School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia., Elveđi Gašparović V; Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, Petrova ulica 13, 10 000 Zagreb, Croatia.; School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia., Škrgatić L; Scientific Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.; Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, Petrova ulica 13, 10 000 Zagreb, Croatia.; School of Medicine, University of Zagreb, Šalata 3, 10 000 Zagreb, Croatia.
Jazyk: angličtina
Zdroj: Biology [Biology (Basel)] 2024 May 14; Vol. 13 (5). Date of Electronic Publication: 2024 May 14.
DOI: 10.3390/biology13050342
Abstrakt: The increase in cancer survival rates has put a focus on ensuring fertility preservation procedures for cancer patients. Ovarian tissue cryopreservation presents the only option for prepubertal girls and patients who require immediate start of treatment and, therefore, cannot undergo controlled ovarian stimulation. We aimed to provide an assessment of stem cells' impact on cryopreserved ovarian tissue grafts in regard to the expression of growth factors, angiogenesis promotion, tissue oxygenation, ovarian follicle survival and restoration of endocrine function. For this systematic review, we searched the Scopus and PubMed databases and included reports of trials using murine and/or human cryopreserved ovarian tissue for transplantation or in vitro culture in combination with mesenchymal stem cell administration to the grafting site. Of the 1201 articles identified, 10 met the criteria. The application of stem cells to the grafting site has been proven to support vascular promotion and thereby shorten the period of tissue hypoxia, which is reflected in the increased number of remaining viable follicles and faster recovery of ovarian endocrine function. Further research is needed before implementing the use of stem cells in OT cryopreservation and transplantation procedures in clinical practice. Complex ethical dilemmas make this process more difficult.
Databáze: MEDLINE