Anti-coronavirus and anti-pulmonary inflammation effects of iridoids, the common component from Chinese herbal medicines for the treatment of COVID-19.
Autor: | Huang DY; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 260 Baichuan St, Hangzhou, 311402, People's Republic of China.; School of Pharmacy and Food Engineering, International Healthcare Innovation Institute, Wuyi University, 99 Yingbin Ave, 529020, Jiangmen, People's Republic of China., Luo YX; School of Pharmacy and Food Engineering, International Healthcare Innovation Institute, Wuyi University, 99 Yingbin Ave, 529020, Jiangmen, People's Republic of China., Zheng WD; School of Pharmacy and Food Engineering, International Healthcare Innovation Institute, Wuyi University, 99 Yingbin Ave, 529020, Jiangmen, People's Republic of China., Wu SY; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 260 Baichuan St, Hangzhou, 311402, People's Republic of China., Huang PQ; School of Pharmacy and Food Engineering, International Healthcare Innovation Institute, Wuyi University, 99 Yingbin Ave, 529020, Jiangmen, People's Republic of China., Jin JW; School of Pharmacy and Food Engineering, International Healthcare Innovation Institute, Wuyi University, 99 Yingbin Ave, 529020, Jiangmen, People's Republic of China., Wu PP; School of Pharmacy and Food Engineering, International Healthcare Innovation Institute, Wuyi University, 99 Yingbin Ave, 529020, Jiangmen, People's Republic of China. wyuchemwpp@126.com., Gan LS; School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, 260 Baichuan St, Hangzhou, 311402, People's Republic of China. lsgan@zcmu.edu.cn.; School of Pharmacy and Food Engineering, International Healthcare Innovation Institute, Wuyi University, 99 Yingbin Ave, 529020, Jiangmen, People's Republic of China. lsgan@zcmu.edu.cn. |
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Jazyk: | angličtina |
Zdroj: | Journal of natural medicines [J Nat Med] 2024 Sep; Vol. 78 (4), pp. 1003-1012. Date of Electronic Publication: 2024 May 22. |
DOI: | 10.1007/s11418-024-01820-3 |
Abstrakt: | The practice of Chinese herbal medicines for the treatment of COVID-19 in China played an essential role for the control of mortality rate and reduction of recovery time. The iridoids is one of the main constituents of many heat-clearing and detoxifying Chinese medicines that were largely planted and frequently used in clinical practice. Twenty-three representative high content iridoids from several staple Chinese medicines were obtained and tested by a SARS-CoV-2 pseudo-virus entry-inhibition assay on HEK-293 T/ACE2 cells, a live HCoV-OC43 virus infection assay on HRT-18 cells, and a SARS-CoV-2 3CL protease inhibitory FRET assay followed by molecular docking simulation. The anti-pulmonary inflammation activities were further evaluated on a TNF-α induced inflammation model in A549 cells and preliminary SARs were concluded. The results showed that specnuezhenide (7), cornuside (12), neonuezhenide (15), and picroside III (21) exhibited promising antiviral activities, and neonuezhenide (15) could inhibit 3CL protease with an IC (© 2024. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.) |
Databáze: | MEDLINE |
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