Genetic variants in miR-146a and miR-196a2 in endometriosis: a Brazilian study.

Autor:	Oliveira GC; Universidade Federal do Triângulo Mineiro - Uberaba (MG), Brazil., Cintra MTR; Universidade Federal do Triângulo Mineiro, Institute of Exact, Natural Sciences and Education - Uberaba (MG), Brazil., Lima MFP; Universidade Federal do Triângulo Mineiro, Institute of Health Sciences - Uberaba (MG), Brazil., Gomes MKO; Universidade Federal do Triângulo Mineiro, Institute of Health Sciences - Uberaba (MG), Brazil., Marqui ABT; Universidade Federal do Triângulo Mineiro, Institute of Biological and Natural Sciences - Uberaba (MG), Brazil.
Jazyk:	angličtina
Zdroj:	Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2024 May 17; Vol. 70 (5), pp. e20231382. Date of Electronic Publication: 2024 May 17 (Print Publication: 2024).
DOI:	10.1590/1806-9282.20231382
Abstrakt:	Objective: The aim of this study was to determine the allelic and genotypic frequencies of the polymorphisms, rs2910164 miR-146a and rs11614913 miR-196a2, by investigating their association with endometriosis. Methods: This is a case-control study performed with approximately 120 women. The polymorphisms were determined by real-time polymerase chain reaction. For the statistical analysis, the chi-square and logistic regression tests were used. Results: There were no significant differences in the genotype and allele frequencies of rs2910164 and rs11614913 between cases and controls. The frequencies in both polymorphisms are in accordance with Hardy-Weinberg equilibrium regarding miR-146a (patients: χ2=1.64, p=0.20; controls: χ2=0.25, p=0.62) and miR-196a2 (patients: χ2=0.58, p=0.44; controls: χ2=2.78, p=0.10). No relationship was observed between rs2910164 and rs11614913 and endometriosis in the inheritance models analyzed. Conclusion: In this study, our results show that the studied polymorphisms are not implicated in the development of endometriosis.
Databáze:	MEDLINE
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