Assessment of sleep parameters in adults with persistent post-concussive symptoms.

Autor: McIntosh SJ; Department of Clinical Neuroscience Division of Physical Medicine and Rehabilitation - University of Calgary, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada; Hotchkiss Brain Institute (HBI), University of Calgary, Calgary, AB, Canada., Mercier LJ; Department of Clinical Neuroscience Division of Physical Medicine and Rehabilitation - University of Calgary, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada; Hotchkiss Brain Institute (HBI), University of Calgary, Calgary, AB, Canada., Boucher C; Department of Clinical Neuroscience Division of Physical Medicine and Rehabilitation - University of Calgary, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada; Hotchkiss Brain Institute (HBI), University of Calgary, Calgary, AB, Canada., Yip R; Faculty of Medicine and Dentistry - University of Alberta, Calgary, AB, Canada., Batycky JM; Department of Clinical Neuroscience Division of Physical Medicine and Rehabilitation - University of Calgary, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada; Hotchkiss Brain Institute (HBI), University of Calgary, Calgary, AB, Canada., Joyce J; Hotchkiss Brain Institute (HBI), University of Calgary, Calgary, AB, Canada; Department of Radiology - University of Calgary, 28 Oki Drive NW, Calgary, AB, T3B 6A8, Canada., Stokoe M; Department of Radiology - University of Calgary, 28 Oki Drive NW, Calgary, AB, T3B 6A8, Canada; Werklund School of Education - University of Calgary, Calgary, AB, Canada., Harris AD; Hotchkiss Brain Institute (HBI), University of Calgary, Calgary, AB, Canada; Department of Radiology - University of Calgary, 28 Oki Drive NW, Calgary, AB, T3B 6A8, Canada; Alberta Children's Hospital Research Institute (ACHRI), University of Calgary, Calgary, AB, Canada., Debert CT; Department of Clinical Neuroscience Division of Physical Medicine and Rehabilitation - University of Calgary, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada; Hotchkiss Brain Institute (HBI), University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital Research Institute (ACHRI), University of Calgary, Calgary, AB, Canada. Electronic address: cdebert@ucalgary.ca.
Jazyk: angličtina
Zdroj: Sleep medicine [Sleep Med] 2024 Jul; Vol. 119, pp. 406-416. Date of Electronic Publication: 2024 May 16.
DOI: 10.1016/j.sleep.2024.05.030
Abstrakt: Objectives: The primary aim of this study was to characterize sleep in adults with persistent post-concussive symptoms (PPCS). Secondary aims explored relationships between sleep parameters, injury characteristics, and symptom questionnaires.
Methods: This case-controlled, cross-sectional study recruited adults (18-65yrs) diagnosed with PPCS and age and sex-matched controls. Participants wore a wrist-worn actigraph for 3-7 nights and completed daily sleep diaries. Participants completed questionnaires examining daytime sleepiness, fatigue, anxiety/depressive symptoms, and sedentariness. Sleep parameters were compared between groups using Mann-Whitney U tests. Secondary analyses used two-way ANOVA and Spearman's rank correlations.
Results: Fifty adults with PPCS (43.7 ± 10.6yrs, 78 % female) and 50 controls (43.6 ± 11.0yrs) were included in this study. Adults with PPCS had significantly longer sleep onset latency (PPCS 16.99 ± 14.51min, Controls 8.87 ± 6.44min, p < 0.001) and total sleep time (PPCS 8.3 ± 1.0hrs, Control 7.6 ± 0.9hrs, p = 0.030) compared to controls, but woke up later (PPCS 7:57:27 ± 1:36:40, Control 7:17:16 ± 0:50:08, p = 0.026) and had poorer sleep efficiency (PPCS 77.9 ± 7.5 %, Control 80.8 ± 6.0 %, p = 0.019) than controls. Adults with PPCS reported more daytime sleepiness (Epworth Sleepiness Scale: PPCS 8.70 ± 4.61, Control 4.28 ± 2.79, p < 0.001) and fatigue (Fatigue Severity Scale: PPCS 56.54 ± 12.92, Control 21.90 ± 10.38, p < 0.001). Injury characteristics did not significantly affect sleep parameters in adults with PPCS. Actigraphy parameters were not significantly correlated to questionnaire measures.
Conclusion: Several actigraphy sleep parameters were significantly altered in adults with PPCS compared to controls, but did not correlate with sleep questionnaires, suggesting both are useful tools in characterizing sleep in PPCS. Further, this study provides potential treatment targets to improve sleep difficulties in adults with PPCS.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Chantel T. Debert reports financial support was provided by New Frontiers in Research. Chantel T. Debert reports financial support was provided by Physical Medicine and Rehabilitation. Chantel T. Debert reports financial support was provided by University of CalgaryHotchkiss Brain Institute. Samantha J. McIntosh reports financial support was provided by University of Calgary. Leah J. Mercier reports financial support was provided by Alberta SPOR Support Unit. Leah J. Mercier reports financial support was provided by Brain Canada Foundation. Leah J. Mercier reports financial support was provided by Integrated Concussion Research Program. Leah J. Mercier reports financial support was provided by University of Calgary. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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