Protein networking: nicotinic acetylcholine receptors and their protein-protein-associations.

Autor: Brockmöller S; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Bavaria, Germany. Sabrina.Brockmoeller@yahoo.de., Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Bavaria, Germany., Rothmiller S; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Bavaria, Germany.
Jazyk: angličtina
Zdroj: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 Jul; Vol. 479 (7), pp. 1627-1642. Date of Electronic Publication: 2024 May 21.
DOI: 10.1007/s11010-024-05032-x
Abstrakt: Nicotinic acetylcholine receptors (nAChR) are complex transmembrane proteins involved in neurotransmission in the nervous system and at the neuromuscular junction. nAChR disorders may lead to severe, potentially fatal pathophysiological states. To date, the receptor has been the focus of basic and applied research to provide novel therapeutic interventions. Since most studies have investigated only the nAChR itself, it is necessary to consider the receptor as part of its protein network to understand or elucidate-specific pathways. On its way through the secretory pathway, the receptor interacts with several chaperones and proteins. This review takes a closer look at these molecular interactions and focuses especially on endoplasmic reticulum biogenesis, secretory pathway sorting, Golgi maturation, plasma membrane presentation, retrograde internalization, and recycling. Additional knowledge regarding the nAChR protein network may lead to a more detailed comprehension of the fundamental pathomechanisms of diseases or may lead to the discovery of novel therapeutic drug targets.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: