The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition.

Autor:	Magrou L; Department of Neural Science, New York University, New York, NY 10003, United States., Joyce MKP; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, United States., Froudist-Walsh S; School of Engineering Mathematics and Technology, University of Bristol, Bristol, BS8 1QU, United Kingdom., Datta D; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, United States., Wang XJ; Department of Neural Science, New York University, New York, NY 10003, United States., Martinez-Trujillo J; Departments of Physiology and Pharmacology, and Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, ON, N6A 3K7, Canada., Arnsten AFT; Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, United States.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 May 02; Vol. 34 (5).
DOI:	10.1093/cercor/bhae174
Abstrakt:	The recent publications of the inter-areal connectomes for mouse, marmoset, and macaque cortex have allowed deeper comparisons across rodent vs. primate cortical organization. In general, these show that the mouse has very widespread, "all-to-all" inter-areal connectivity (i.e. a "highly dense" connectome in a graph theoretical framework), while primates have a more modular organization. In this review, we highlight the relevance of these differences to function, including the example of primary visual cortex (V1) which, in the mouse, is interconnected with all other areas, therefore including other primary sensory and frontal areas. We argue that this dense inter-areal connectivity benefits multimodal associations, at the cost of reduced functional segregation. Conversely, primates have expanded cortices with a modular connectivity structure, where V1 is almost exclusively interconnected with other visual cortices, themselves organized in relatively segregated streams, and hierarchically higher cortical areas such as prefrontal cortex provide top-down regulation for specifying precise information for working memory storage and manipulation. Increased complexity in cytoarchitecture, connectivity, dendritic spine density, and receptor expression additionally reveal a sharper hierarchical organization in primate cortex. Together, we argue that these primate specializations permit separable deconstruction and selective reconstruction of representations, which is essential to higher cognition. (© The Author(s) 2024. Published by Oxford University Press.)
Databáze:	MEDLINE
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