Gender and age differences in the associations between cortical thickness and hand osteoarthritis severity: data from the Osteoarthritis Initiative.

Autor: Smith SE; Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: ssmith@bwh.harvard.edu., Driban JB; Department of Population and Quantitative Health Sciences, UMass Chan Medical School, Worcester, MA, USA. Electronic address: jdriban@gmail.com., Eaton CB; Department of Family Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA; Center for Primary Care and Prevention, Kent Hospital, Warwick, RI, USA. Electronic address: cbeaton51@gmail.com., Schaefer LF; Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: lenafranziskaschaefer@yahoo.com., Miao QR; Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: rui_miao@dfci.harvard.edu., Roberts MB; Center for Primary Care and Prevention, Kent Hospital, Warwick, RI, USA. Electronic address: mary_roberts@brown.edu., Cauley JA; Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: jcauley@pitt.edu., McAlindon TE; Division of Rheumatology, Allergy, and Immunology, Tufts Medical Center, Boston, MA, USA. Electronic address: timothy.mcalindon@tuftsmedicine.org., Duryea J; Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: jduryea@bwh.harvard.edu.
Jazyk: angličtina
Zdroj: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2024 Sep; Vol. 32 (9), pp. 1141-1148. Date of Electronic Publication: 2024 May 18.
DOI: 10.1016/j.joca.2024.05.002
Abstrakt: Objective: To evaluate gender differences in the association between metacarpal cortical thickness (T cort )-a surrogate for bone density-and severity of radiographic hand osteoarthritis (HOA) in a longitudinal observational study.
Method: Hand radiographs of 3575 participants (2039 F/1536 M) from the Osteoarthritis Initiative were assessed at baseline and 48 months. A reader used a semi-automated software tool to calculate T cort , a measurement of the cortical thickness, for metacarpals 2-4. Average T cort at baseline and change in T cort from baseline to 48 months was determined and stratified by gender and age for 7 5-year age groups. Spearman's rank correlation coefficients were calculated for the association of baseline T cort and 2 measures of baseline HOA severity: the sum of Kellgren-Lawrence (KL) grade and total number of joints with radiographic HOA. Longitudinally, logistic regression was used to assess the relationship of T cort loss to new finger joint radiographic HOA, increase in KL grades, and incident hand pain.
Results: Male T cort was higher than females. Significant correlations between T cort and radiographic severity were noted for women but not men, with stronger associations among women >60 years (rho = -0.25; 95% confidence interval (CI) = -0.31 to -0.19). Statistically significant associations were seen between T cort change and radiographic osteoarthritis change among women but not men, with substantial gender differences for T cort change, particularly ages 50 to 70 years (p < 0.01; e.g., T cort change ages 55 to <60: males = -0.182 (0.118), females = -0.219 (0.124)).
Conclusion: We found significant HOA-related gender differences in T cort , suggesting the involvement of female bone loss during and after menopause.
(Copyright © 2024 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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