Bioaccumulation of Microplastics in Decedent Human Brains Assessed by Pyrolysis Gas Chromatography-Mass Spectrometry.
| Autor: | Campen M; University of New Mexico., Nihart A; University of New Mexico., Garcia M; University of New Mexico., Liu R; University of New Mexico., Olewine M; University of New Mexico., Castillo E; University of New Mexico., Bleske B; University of New Mexico., Scott J; Oklahoma State University., Howard T; University of New Mexico Health Sciences Center., Gonzalez-Estrella J; Oklahoma State University., Adolphi N; New Mexico Office of the Medical Investigator., Gallego D; New Mexico Office of the Medical Investigator., Hayek EE; University of New Mexico. |
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| Jazyk: | angličtina |
| Zdroj: | Research square [Res Sq] 2024 May 06. Date of Electronic Publication: 2024 May 06. |
| DOI: | 10.21203/rs.3.rs-4345687/v1 |
| Abstrakt: | Rising global concentrations of environmental micro- and nanoplastics (MNPs) drive concerns for human exposure and health outcomes. Applying pyrolysis gas chromatography-mass spectrometry (Py-GC/MS) methods to isolate and quantify MNPs from human samples, we compared MNP accumulation in kidneys, livers, and brains. Autopsy samples from the Office of the Medical Investigator in Albuquerque, NM, collected in 2016 and in 2024, were digested for Py-GC/MS analysis of 12 polymers. Brains exhibited higher concentrations of MNPs than liver or kidney samples. All organs exhibited significant increases from 2016 to 2024. Polyethylene was the predominant polymer; the relative proportion of polyethylene MNPs was greater in brain samples than in liver or kidney. Transmission electron microscopy verified the nanoscale nature of isolated particles, which largely appeared to be aged, shard-like plastics remnants across a wide range of sizes. Results demonstrate that MNPs are selectively accumulated into the human brain and concentrations are rising over time. Competing Interests: Statement of Interests: The authors declare no conflicts of interest with the content of this manuscript. |
| Databáze: | MEDLINE |
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