Seroprotection against tetanus in the Italian general population.

Autor: Bagordo F; Dept. of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy., Grassi T; Dept. of Experimental Medicine, University of Salento, Lecce, Italy. Electronic address: tiziana.grassi@unisalento.it., Rota MC; Dept. of Infectious Diseases, Italian Institute of Health (ISS), Roma, Italy., Castiglia P; Dept. of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy., Baldovin T; Dept. of Cardiac, Thoracic, Vascular Sciences and Public Health, Hygiene and Public Health Unit, University of Padua, Padua, Italy., Della Polla G; Dept. of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Panico A; Dept. of Experimental Medicine, University of Salento, Lecce, Italy., Ogliastro M; Dept. of Health Sciences, University of Genova, Genova, Italy., Marchi S; Dept. of Molecular and Developmental Medicine, University of Siena, Siena, Italy., Vicentini C; Department of Public Health and Paediatrics, University of Turin, Turin, Italy., Immordino P; Dept. of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties 'G. D'Alessandro', University of Palermo, Palermo, Italy., Savio M; Dept. of Public Health, OU of Hygiene, LHU Ferrara, Ferrara, Italy., Gabutti G; National Coordinator of the Working Group 'Vaccines and Immunization Policies', Italian Society of Hygiene, Preventive Medicine and Public Health, Italy.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Jul 25; Vol. 42 (19), pp. 4040-4045. Date of Electronic Publication: 2024 May 18.
DOI: 10.1016/j.vaccine.2024.05.015
Abstrakt: Background: Tetanus is a non-communicable disease, preventable with vaccination. Despite the implemented vaccination strategy, a certain number of tetanus cases per year continue to occur. The aim of the study was to evaluate the seroprevalence of anti-tetanus antibodies in the Italian population by age, sex and geographical area.
Methods: To determine the level of tetanus-specific antibodies, an immunoenzymatic assay was used.
Results: A total of 3,821 serum samples were collected in the years 2019-20 from healthy subjects aged 6-90 years residing in 13 Italian regions. Overall, 85 % of the tested subjects resulted positive. The rate of subjects protected against tetanus showed a gradual decrease from the younger age groups to the older ones (6-12 years: 93.6 %, 13-24 years: 91.8 %, 25-39 years: 91.0 %, 40-64 years: 78.2 %, ≥ 65 years: 45.3 %); this is particularly evident in the Southern regions and Islands. Moreover, the prevalence of subjects with low protection (<0.1 IU/ml) was significantly higher in the ≥ 65 age group (10.3 %). Males and females' prevalence showed a significant difference only in the oldest age group (M: 60.8 %, F: 30.4 %). In general, a higher prevalence was observed for Northern (90.8 %) and Central regions (87.3 %) than Southern regions and Islands (80.0 %).
Conclusion: These data, compared with epidemiological ones which showed a high number of cases in the elderly, confirmed that the population with lower protection has a greater risk of contracting the disease, demonstrating the need for adequate immunization through both primary vaccination and boosters for all ages and both sexes, in order to provide lifelong protection.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Giovanni Gabutti reports a relationship with Emergent BioSolutions, the GSK group of companies, Merck Sharp & Dohme, Pfizer, Sanofi Pasteur Italy, Novavax, Viatris, Moderna and Seqirus that includes: board membership, consulting or advisory, and speaking and lecture fees. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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