Neonatal neurobehavior associated with developmental changes from age 2 to 3 in very preterm infants.

Autor: Craft AL; Women and Infants Hospital, Providence, RI, United States of America; Warren Alpert Medical School of Brown University, Providence, RI, United States of America. Electronic address: Alexandrea_craft@brown.edu., Camerota M; Women and Infants Hospital, Providence, RI, United States of America; Warren Alpert Medical School of Brown University, Providence, RI, United States of America., Loncar C; Women and Infants Hospital, Providence, RI, United States of America., Carter BS; Children's Mercy Hospital, Kansas City, MO, United States of America., Check J; Wake Forest School of Medicine, Winston-Salem, NC, United States of America., Helderman JB; Wake Forest School of Medicine, Winston-Salem, NC, United States of America., Hofheimer JA; UNC School of Medicine, Chapel Hill, NC, United States of America., McGowan EC; Women and Infants Hospital, Providence, RI, United States of America; Warren Alpert Medical School of Brown University, Providence, RI, United States of America., Neal CR; University of Hawaii John A. Burns School of Medicine, Honolulu, HI, United States of America., O'Shea TM; UNC School of Medicine, Chapel Hill, NC, United States of America., Pastyrnak SL; Spectrum Health-Helen Devos Hospital, Grand Rapids, MI, United States of America., Smith LM; Harbor-UCLA Medical Center, Torrance, CA, United States of America., Dansereau LM; Women and Infants Hospital, Providence, RI, United States of America., DellaGrotta SA; Women and Infants Hospital, Providence, RI, United States of America., Marsit C; Rollins School of Public Health of Emory University, Atlanta, GA, United States of America., Lester BM; Women and Infants Hospital, Providence, RI, United States of America; Warren Alpert Medical School of Brown University, Providence, RI, United States of America.
Jazyk: angličtina
Zdroj: Early human development [Early Hum Dev] 2024 Jul; Vol. 194, pp. 106039. Date of Electronic Publication: 2024 May 14.
DOI: 10.1016/j.earlhumdev.2024.106039
Abstrakt: Objective: Understand how high-risk infants' development changes over time. Examine whether NICU Network Neurobehavioral Scale (NNNS) profiles are associated with decrements in developmental outcomes between ages 2 and 3 years in infants born very preterm.
Study Design: The Neonatal Outcomes for Very preterm Infants (NOVI) cohort is a multisite prospective study of 704 preterm infants born <30 weeks' gestation across nine university and VON affiliated NICUs. Data included infant neurobehavior measured by NNNS profiles at NICU discharge and the Bayley Scales of Infant and Toddler Development (BSID-III) at ages 2 and 3 years. Generalized estimating equations tested associations between NNNS profiles and BSID-III composite score changes between ages 2 and 3 years.
Results: The final study sample included 433 infants with mean gestational age of 27 weeks at birth. Infants with dysregulated NNNS profiles were more likely to have decreases in BSID-III Cognitive (OR = 2.66) and Language scores (OR = 2.53) from age 2 to 3 years compared to infants with more well-regulated neurobehavioral NNNS profiles. Further, infants with more well-regulated NNNS profiles were more likely to have increases in BSID-III Cognitive scores (OR = 2.03), rather than no change, compared to infants with dysregulated NNNS profiles.
Conclusions and Relevance: Prior to NICU discharge, NNNS neurobehavioral profiles identified infants at increased risk for developing later language and cognitive challenges. Findings suggests that neonatal neurobehavior provides a unique, clinically significant contribution to the evaluation of very preterm infants to inform treatment planning for the most vulnerable.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest relevant to this article to disclose.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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