Effects of fish-human transmission and different life stages of fish on Clonorchiasis: A novel mathematical model.

Autor: Wang W; College of Mathematics and Systems Science, Shandong University of Science and Technology, Qingdao 266590, China. Electronic address: weiwang10437@sdust.edu.cn., Huang X; College of Mathematics and Systems Science, Shandong University of Science and Technology, Qingdao 266590, China. Electronic address: xiaohuihuang@sdust.edu.cn., Wang H; Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB T6G 2G1, Canada. Electronic address: hao8@ualberta.ca.
Jazyk: angličtina
Zdroj: Mathematical biosciences [Math Biosci] 2024 Jul; Vol. 373, pp. 109209. Date of Electronic Publication: 2024 May 15.
DOI: 10.1016/j.mbs.2024.109209
Abstrakt: Clonorchiasis is a zoonotic disease mainly caused by eating raw fish and shrimp, and there is no vaccine to prevent it. More than 30 million people are infected worldwide, of which China alone accounts for about half, and is one of the countries most seriously affected by Clonorchiasis. In this work, we formulate a novel Ordinary Differential Equation (ODE) model to discuss the biological attributes of fish within authentic ecosystems and the complex lifecycle of Clonorchis sinensis. This model includes larval fish, adult fish, infected fish, humans, and cercariae. We derive the basic reproduction number and perform a rigorous stability analysis of the proposed model. Numerically, we use data from 2016 to 2021 in Guangxi, China, to discuss outbreaks of Clonorchiasis and obtain the basic reproduction number R 0 =1.4764. The fitted curve appropriately reflects the overall trend and replicates a low peak in the case number of Clonorchiasis. By reducing the release rate of cercariae in 2018, the fitted values of Clonorchiasis cases dropped rapidly and almost disappeared. If we decrease the transmission rate from infected fish to humans, Clonorchiasis can be controlled. Our studies also suggest that strengthening publicity education and cleaning water quality can effectively control the transmission of Clonorchiasis in Guangxi, China.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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